2. Gene
  3. TMBIM1 - transmembrane BAX inhibitor motif containing 1 Gene

TMBIM1 - transmembrane BAX inhibitor motif containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as LFG3; RECS1; MST100; PP1201; MSTP100

Gene ID: 64114 | Gene type: protein coding

About TMBIM1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,274,197-218,292,503 (from NCBI)

This gene has 23 transcripts (splice variants), 254 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 69.4), fat (RPKM 68.5) and 25 other tissues.

Summary

Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMBIM1 Products(10)

mRNA Protein Name
NM_001321427.2 NP_001308356.1 protein lifeguard 3 isoform 1
NM_001321428.2 NP_001308357.1 protein lifeguard 3 isoform 1
NM_001321429.2 NP_001308358.1 protein lifeguard 3 isoform 1
NM_001321430.2 NP_001308359.1 protein lifeguard 3 isoform 1
NM_001321432.2 NP_001308361.1 protein lifeguard 3 isoform 1
NM_001321433.2 NP_001308362.1 protein lifeguard 3 isoform 1
NM_001321435.2 NP_001308364.1 protein lifeguard 3 isoform 1
NM_001321436.2 NP_001308365.1 protein lifeguard 3 isoform 1
NM_001321438.2 NP_001308367.1 protein lifeguard 3 isoform 2
NM_022152.6 NP_071435.2 protein lifeguard 3 isoform 1

TMBIM1 Protein Structure

Bax1-I

Bax1-I: Inhibitor of apoptosis-promoting Bax1 (97 - 307)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

protein lifeguard 3

transmembrane BAX inhibitor motif-containing protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14618 TMBIM1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMBIM1 VGNC VGNC:66232
Rattus norvegicus TMBIM1 RGD RGD:1359409
Canis familiaris TMBIM1 VGNC VGNC:49789
Macaca mulatta TMBIM1 VGNC VGNC:79392
Mus musculus TMBIM1 MGD MGI:1916910
Bos taurus TMBIM1 VGNC VGNC:35915