GGT6 - gamma-glutamyltransferase 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 124975

About GGT6

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,556,140-4,560,577 (from NCBI)

This gene has 6 transcripts (splice variants), 122 orthologues and 6 paralogues. Biased expression in colon (RPKM 26.8), kidney (RPKM 22.6) and 12 other tissues.

Summary

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and Other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

GGT6 Products (5)

mRNA Protein Name
NM_001122890.3 NP_001116362.1 glutathione hydrolase 6 isoform a
NM_001288702.2 NP_001275631.1 glutathione hydrolase 6 isoform c
NM_001288703.2 NP_001275632.1 glutathione hydrolase 6 isoform d
NM_001288704.2 NP_001275633.1 glutathione hydrolase 6 isoform e
NM_153338.4 NP_699169.2 glutathione hydrolase 6 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGT6 Protein Structure

G_glu_transpept

G_glu_transpept: Gamma-glutamyltranspeptidase (117 - 261)

G_glu_transpept

G_glu_transpept: Gamma-glutamyltranspeptidase (347 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

glutathione hydrolase 6

  • gamma-glutamyltransferase 6 homolog

GGT6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GGT6 Q6P531 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
Intra
GGT6 Q6P531 TMBIM1 Homo sapiens Q969X1
Validated Y2H
32296183
Intra
GGT6 Q6P531 GRINA Homo sapiens Q7Z429
Validated Y2H
32296183
Intra
GGT6 Q6P531 FAM3C Homo sapiens Q92520
Validated Y2H
32296183
Intra
GGT6 Q6P531 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Intra
GGT6 Q6P531 FAIM2 Homo sapiens Q9BWQ8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glutathionuria

  • Gamma-Glutamyltransferase Deficiency

  • Ggt Deficiency

  • Gtg Deficiency

  • Gamma-Glutamyltranspeptidase Deficiency

  • Glutathioninuria

  • Gamma-Glutamyl Transpeptidase Deficiency

  • Gamma-Glutamyl Transferase Deficiency

  • Ggt1 Deficiency

  • GLUTH
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05405 GGT6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GGT6 VGNC VGNC:29345
Felis catus GGT6 VGNC VGNC:99063
Macaca mulatta GGT6 VGNC VGNC:104603
Mus musculus GGT6 MGD MGI:1918772
Rattus norvegicus GGT6 RGD RGD:1303335
Canis familiaris GGT6 VGNC VGNC:41202
Others GGT6 NCBI