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FAIM2 - Fas apoptotic inhibitory molecule 2 Gene

Also Known as LFG; LFG2; NGP35; NMP35; TMBIM2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23017

About FAIM2

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,866,896-49,903,900 (from NCBI)

This gene has 7 transcripts (splice variants), 259 orthologues and 5 paralogues. Biased expression in brain (RPKM 125.6) and adrenal (RPKM 12.3).

Summary

Involved in regulation of neuron apoptotic process. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in membrane raft. [provided by Alliance of Genome Resources, Apr 2022]

FAIM2 Products (1)

mRNA	Protein	Name
NM_012306.4	NP_036438.2	protein lifeguard 2

FAIM2 Protein Structure

Bax1-I

0
100
200
300
316 a.a.

Protein Preferred Names	Protein Names
protein lifeguard 2	neural membrane protein 35

FAIM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FAIM2	Q9BWQ8	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	FAIM2	Q9BWQ8	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	FAIM2	Q9BWQ8	GGT6	Homo sapiens	Q6P531	Y2H Prey Pooling	32296183
Intra	FAIM2	Q9BWQ8	GGT6	Homo sapiens	Q6P531	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04675	FAIM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20922	Faim2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27439	Faim2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FAIM2	VGNC	VGNC:62043
Mus musculus	FAIM2	MGD	MGI:1919643
Canis familiaris	FAIM2	VGNC	VGNC:40571
Bos taurus	FAIM2	VGNC	VGNC:28710
Macaca mulatta	FAIM2	VGNC	VGNC:72286
Rattus norvegicus	FAIM2	RGD	RGD:628744
Others	FAIM2	NCBI