1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. Bcr-Abl
    Autophagy

Bafetinib (Synonyms: INNO-406; NS-187)

Cat. No.: HY-50868 Purity: 99.80%
Handling Instructions

Bafetinib is a Lyn and Bcr-Abl tyrosine kinase inhibitor with potential antineoplastic activity.

For research use only. We do not sell to patients.

Bafetinib Chemical Structure

Bafetinib Chemical Structure

CAS No. : 859212-16-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 114 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 156 In-stock
Estimated Time of Arrival: December 31
50 mg USD 468 In-stock
Estimated Time of Arrival: December 31
100 mg USD 576 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

    Bafetinib purchased from MCE. Usage Cited in: Science. 2017 Dec 1;358(6367).

    Kinobead western Blot readout for selected inhibitor:protein combinations.

    Bafetinib purchased from MCE. Usage Cited in: Science. 2017 Dec 1;358(6367).

    Immunoblot analysis in MV-4-11 cells and MOLM-13, FLT3-WT and FLT3-ITD transfected HEK293 cells, and Ba/F3 FLT3-ITD cells revealed FLT3 target engagement for Golvatinib and Cabozantinib.

    Bafetinib purchased from MCE. Usage Cited in: Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

    Western blot analysis of selected MAPK and AKT/mTOR pathway components in Trametinib- and Temsirolimus-treated cells.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Bafetinib is a Lyn and Bcr-Abl tyrosine kinase inhibitor with potential antineoplastic activity.

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 42 mg/mL (72.84 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7342 mL 8.6712 mL 17.3424 mL
    5 mM 0.3468 mL 1.7342 mL 3.4685 mL
    10 mM 0.1734 mL 0.8671 mL 1.7342 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    576.62

    Formula

    C₃₀H₃₁F₃N₈O

    CAS No.

    859212-16-1

    SMILES

    O=C(C1=CC=C(C(C(F)(F)F)=C1)CN2C[[email protected]@H](N(C)C)CC2)NC3=CC=C(C)C(NC4=NC=CC(C5=CN=CN=C5)=N4)=C3

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

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    The molarity calculator equation

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    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Bafetinib
    Cat. No.:
    HY-50868
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    Bafetinib

    Cat. No.: HY-50868