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CCT3 - chaperonin containing TCP1 subunit 3 Gene

Also Known as CCTG; PIG48; TRIC5; CCT-gamma; TCP-1-gamma

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7203

About CCT3

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,308,968-156,338,292 (from NCBI)

This gene has 16 transcripts (splice variants), 238 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 72.7), adrenal (RPKM 56.4) and 25 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

CCT3 Products (2)

mRNA	Protein	Name
NM_001008800.3	NP_001008800.1	T-complex protein 1 subunit gamma isoform c
NM_005998.5	NP_005989.3	T-complex protein 1 subunit gamma isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12620389	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	25467444	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chaperone mediated protein folding independent of cofactor	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	22133715	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	30955883	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25467444	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of chaperonin-containing T-complex	IDA IDA: Inferred from direct assay	23011926	GOA
part of chaperonin-containing T-complex	IPI IPI: Inferred from physical interaction	22133715	GOA
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCT3 Protein Structure

Cpn60_TCP1

0
100
200
300
400
500
545 a.a.

Protein Preferred Names	Protein Names
T-complex protein 1 subunit gamma	T-complex protein 1, gamma subunit

CCT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCT3	P49368	POLR1C	Homo sapiens	O15160	Y2H Array	32296183
Intra	CCT3	P49368	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	32296183
Intra	CCT3	P49368	DEPDC5	Homo sapiens	O75140-2	Y2H Prey Pooling	32296183
Intra	CCT3	P49368	DEPDC5	Homo sapiens	O75140-2	Y2H Array	32296183
Intra	CCT3	P49368	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	25416956
Intra	CCT3	P49368	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
Intra	CCT3	P49368	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	CCT3	P49368	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	32296183
Intra	CCT3	P49368	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	CCT3	P49368	GEMIN4	Homo sapiens	P57678	Validated Y2H	32296183
Intra	CCT3	P49368	GEMIN4	Homo sapiens	P57678	Y2H Prey Pooling	32296183
Intra	CCT3	P49368	GEMIN4	Homo sapiens	P57678	Y2H Array	32296183
Intra	CCT3	P49368	PDCL	Homo sapiens	Q13371	Y2H Array	32296183
Intra	CCT3	P49368	PDCL	Homo sapiens	Q13371	Validated Y2H	32296183
Intra	CCT3	P49368	PDCL	Homo sapiens	Q13371	Anti Tag CoIP	33961781
Intra	CCT3	P49368	PDCL	Homo sapiens	Q13371	Anti Tag CoIP	28514442
Intra	CCT3	P49368	PDCL	Homo sapiens	Q13371	Y2H Prey Pooling	32296183
Intra	CCT3	P49368	UBE2Z	Homo sapiens	Q9H832	Validated Y2H	32296183
Intra	CCT3	P49368	ZNRD2	Homo sapiens	O60232	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02180	CCT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CCT3	VGNC	VGNC:70746
Rattus norvegicus	CCT3	RGD	RGD:735038
Felis catus	CCT3	VGNC	VGNC:60577
Mus musculus	CCT3	MGD	MGI:104708
Canis familiaris	CCT3	VGNC	VGNC:38923
Bos taurus	CCT3	VGNC	VGNC:26996
Others	CCT3	NCBI