ATP5PO - ATP synthase peripheral stalk subunit OSCP Gene

Also Known as ATPO; OSCP; ATP5O; HMC08D05

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 539

About ATP5PO

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,903,453-33,915,804 (from NCBI)

This gene has 11 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in heart (RPKM 296.0), duodenum (RPKM 137.0) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]

ATP5PO Products (1)

mRNA Protein Name
NM_001697.3 NP_001688.1 ATP synthase subunit O, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: Inferred from direct assay
12110673 GOA
Biological Process GO Annotation Evidence References Source
involved in proton motive force-driven mitochondrial ATP synthesis IMP
IMP: Inferred from mutant phenotype
15850986 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
12110673 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17851741 GOA
part of proton-transporting ATP synthase complex IDA
IDA: Inferred from direct assay
12110673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5PO Protein Structure

OSCP

OSCP: ATP synthase delta (OSCP) subunit (37 - 209)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

ATP synthase subunit O, mitochondrial

  • ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

ATP5PO Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATP5PO P48047 CCDC136 Homo sapiens Q96JN2-2
Y2H Prey Pooling
25416956
Intra
ATP5PO P48047 CCDC136 Homo sapiens Q96JN2-2
Validated Y2H
25416956
Intra
ATP5PO P48047 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra
ATP5PO P48047 TEX13A Homo sapiens Q9BXU3
Y2H Prey Pooling
32296183
Intra
ATP5PO P48047 TEX13A Homo sapiens Q9BXU3
Validated Y2H
32296183
Intra
ATP5PO P48047 TEX13A Homo sapiens Q9BXU3
Y2H Array
32296183
Intra
ATP5PO P48047 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra
ATP5PO P48047 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra
ATP5PO P48047 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
Intra
ATP5PO P48047 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
25416956
Intra
ATP5PO P48047 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra
ATP5PO P48047 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ATP5PO P48047 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ATP5PO P48047 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
ATP5PO P48047 NDC80 Homo sapiens O14777
Y2H Prey Pooling
25416956
Intra
ATP5PO P48047 NDC80 Homo sapiens O14777
Y2H Array
25416956
Intra
ATP5PO P48047 NDC80 Homo sapiens O14777
Validated Y2H
25416956
Intra
ATP5PO P48047 PPID Homo sapiens Q08752
Pull Down
30266287
Intra
ATP5PO P48047 PPID Homo sapiens Q08752
Anti Bait CoIP
30266287
Intra
ATP5PO P48047 KRT15 Homo sapiens P19012
Validated Y2H
25416956
Intra
ATP5PO P48047 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra
ATP5PO P48047 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra
ATP5PO P48047 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
ATP5PO P48047 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
ATP5PO P48047 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
ATP5PO P48047 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra
ATP5PO P48047 NT5C2 Homo sapiens P49902
Y2H Prey Pooling
25416956
Intra
ATP5PO P48047 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra
ATP5PO P48047 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092
Pull Down
30266287
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leigh Syndrome

  • Leigh Disease

  • Infantile Subacute Necrotizing Encephalopathy

  • Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

  • LS

  • Sne

  • Leigh'S Disease

  • Leigh Syndrome Due To Mitochondrial Complex I Deficiency

  • Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

  • Subacute Necrotizing Encephalomyelopathy

  • Necrotizing Encephalopathy Infantile Subacute Of Leigh

  • Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

  • Infantile Necrotizing Encephalomyelopathy

  • Juvenile Subacute Necrotizing Encephalomyelopathy

  • Leigh'S Necrotizing Encephalopathy

  • Subacute Necrotizing Encephalopathy

  • Juvenile Subacute Necrotizing Encephalopathy

  • Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

  • Leigh Syndrome Due To Mitochondrial Complex V Deficiency

  • Encephalopathy, Subacute Necrotizing, Infantile

  • Encephalopathy, Subacute Necrotizing, Juvenile

  • Maternally Inherited Leigh Syndrome

  • Subacute Necrotising Encephalomyelopathy

  • Subacute Necrotising Encephalopathy
Graves' Disease

  • Graves Disease

  • Exophthalmic Goiter

  • Basedow'S Disease

  • Grave'S Disease

  • Basedow Disease

  • Toxic Diffuse Goiter

  • Graves' Hyperthyroidism

  • Parry Disease

  • Autoimmune Hyperthyroidism

  • Toxic Multinodular Goiter
Hashimoto Thyroiditis

  • Autoimmune Thyroiditis

  • Hashimoto Struma

  • Hashimoto'S Thyroiditis

  • Chronic Lymphocytic Thyroiditis

  • Lymphocytic Thyroiditis

  • Hashimoto Disease

  • Ht

  • Hashimoto'S Disease

  • Hashimoto'S Syndrome

  • Hypothyroidism, Autoimmune

  • Autoimmune Chronic Lymphocytic Thyroiditis

  • Chronic Lymphocytic Thyroiditides

  • Hashimoto Syndrome

  • Hashimotos Thyroiditis

  • Hashimoto Thyroiditis, Susceptibility To

  • Thyroiditis, Autoimmune

  • Lymphomatous Thyroiditis

  • Lymphoid Thyroiditis

  • Chronic Lymphadenoid Thyroiditis

  • Autoimmune Lymphocytic Chronic Thyroiditis

  • Goitre Lymphomatosa

  • Hashitoxicosis

  • Hashimoto Hypothyroidism

  • Lymphadenoid Goitre

  • Struma Lymphomatosa

  • Hyperthyroidism With Hashimoto Disease

  • Hashimoto Thyrotoxicosis

  • Thyrotoxicosis Due To Hashimoto Thyroiditis

  • Struma Lymphomatosis

  • Lymphadenoid Struma
Goiter

  • Goitre
Hypotropia
Subacute Thyroiditis

  • Giant-Cell Thyroiditis

  • Granulomatous Thyroiditis

  • Subacute Granulomatous Thyroiditis

  • De Quervain'S Thyroiditis

  • Thyroiditis Subacute

  • Thyroiditis, Subacute

  • Pseudogranulomatous Thyroiditis

  • De Quervain Thyroiditis

  • Nonsuppurative Subacute Thyroiditis

  • Pseudotuberculous Thyroiditis

  • Nonsuppurative Thyroiditis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01213 ATP5PO Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATP5PO MGD MGI:106341
Rattus norvegicus ATP5PO RGD RGD:621379
Others ATP5PO NCBI