DNTTIP1 - deoxynucleotidyltransferase terminal interacting protein 1 Gene

Also Known as Tdif1; C20orf167; dJ447F3.4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116092

About DNTTIP1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,791,954-45,811,418 (from NCBI)

This gene has 6 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 14.1), bone marrow (RPKM 12.1) and 25 other tissues.

Summary

DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA Polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]

DNTTIP1 Products (1)

mRNA Protein Name
NM_052951.3 NP_443183.1 deoxynucleotidyltransferase terminal-interacting protein 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11473582 GOA
enables nucleosome binding IDA
IDA: Inferred from direct assay
25653165 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11473582 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11473582 GOA
Cellular Component GO Annotation Evidence References Source
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
25653165 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11473582 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deoxynucleotidyltransferase terminal-interacting protein 1

  • TdT binding protein

DNTTIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNTTIP1 Q9H147 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
Intra
DNTTIP1 Q9H147 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
Intra
DNTTIP1 Q9H147 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
DNTTIP1 Q9H147 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
DNTTIP1 Q9H147 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
DNTTIP1 Q9H147 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
DNTTIP1 Q9H147 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
DNTTIP1 Q9H147 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
DNTTIP1 Q9H147 TSC1 Homo sapiens Q86WV8
Validated Y2H
32814053
Intra
DNTTIP1 Q9H147 TSC1 Homo sapiens Q86WV8
Y2H Array
32814053
Intra
DNTTIP1 Q9H147 TSC1 Homo sapiens Q86WV8
Y2H Pooling
32814053
Intra
DNTTIP1 Q9H147 TOR1A Homo sapiens O14656-2
Y2H Pooling
32814053
Intra
DNTTIP1 Q9H147 TOR1A Homo sapiens O14656-2
Validated Y2H
32814053
Intra
DNTTIP1 Q9H147 TOR1A Homo sapiens O14656-2
Y2H Array
32814053
Intra
DNTTIP1 Q9H147 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
DNTTIP1 Q9H147 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
DNTTIP1 Q9H147 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
DNTTIP1 Q9H147 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
DNTTIP1 Q9H147 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
DNTTIP1 Q9H147 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
DNTTIP1 Q9H147 A2M Homo sapiens P01023
Validated Y2H
32814053
Intra
DNTTIP1 Q9H147 A2M Homo sapiens P01023
Y2H Array
32814053
Intra
DNTTIP1 Q9H147 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra
DNTTIP1 Q9H147 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32814053
Intra
DNTTIP1 Q9H147 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
32814053
Intra
DNTTIP1 Q9H147 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32814053
Intra
DNTTIP1 Q9H147 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
DNTTIP1 Q9H147 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
DNTTIP1 Q9H147 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymph Node Carcinoma

  • Lymph Node Cancer

  • Lymph Node Neoplasm

  • Neoplasm Of Lymph Node
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03917 DNTTIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DNTTIP1 VGNC VGNC:40040
Rattus norvegicus DNTTIP1 RGD RGD:621627
Felis catus DNTTIP1 VGNC VGNC:61566
Macaca mulatta DNTTIP1 VGNC VGNC:71845
Mus musculus DNTTIP1 MGD MGI:1923483
Bos taurus DNTTIP1 VGNC VGNC:28151
Others DNTTIP1 NCBI