GNL3L - G protein nucleolar 3 like Gene

Also Known as GNL3B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54552

About GNL3L

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:54,530,219-54,645,854 (from NCBI)

This gene has 12 transcripts (splice variants), 188 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 3.6), appendix (RPKM 3.3) and 25 other tissues.

Summary

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GNL3L Products (2)

mRNA Protein Name
NM_001184819.2 NP_001171748.1 guanine nucleotide-binding protein-like 3-like protein
NM_019067.6 NP_061940.1 guanine nucleotide-binding protein-like 3-like protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
19487455 GOA
involved in negative regulation of protein sumoylation IMP
IMP: Inferred from mutant phenotype
22641345 GOA
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
19487455 GOA
involved in negative regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
18082603 GOA
involved in positive regulation of protein localization to chromosome, telomeric region IDA
IDA: Inferred from direct assay
19487455 GOA
involved in positive regulation of protein localization to chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
19487455 GOA
involved in positive regulation of protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
19487455 GOA
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
19487455 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
19487455 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
18082603 GOA
part of telomerase holoenzyme complex IDA
IDA: Inferred from direct assay
18082603 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNL3L Protein Structure

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (254 - 315)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein-like 3-like protein

  • G protein nucleolar 3B

GNL3L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNL3L Q9NVN8 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
GNL3L Q9NVN8 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
GNL3L Q9NVN8 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Array
31515488
Intra
GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
25416956
Intra
GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
Intra
GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
25416956
Intra
GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Array
25416956
Intra
GNL3L Q9NVN8 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
GNL3L Q9NVN8 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra
GNL3L Q9NVN8 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
GNL3L Q9NVN8 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
GNL3L Q9NVN8 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra
GNL3L Q9NVN8 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 MDM2 Homo sapiens Q00987
Anti Bait CoIP
21132010
Intra
GNL3L Q9NVN8 MDM2 Homo sapiens Q00987
Anti Tag CoIP
21132010
Intra
GNL3L Q9NVN8 MDM2 Homo sapiens Q00987
Confocal
21132010
Intra
GNL3L Q9NVN8 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
GNL3L Q9NVN8 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
GNL3L Q9NVN8 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 LDOC1 Homo sapiens O95751
Y2H Array
31515488
Intra
GNL3L Q9NVN8 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra
GNL3L Q9NVN8 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05567 GNL3L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GNL3L VGNC VGNC:41328
Mus musculus GNL3L MGD MGI:2448557
Felis catus GNL3L VGNC VGNC:62627
Rattus norvegicus GNL3L RGD RGD:1600217
Macaca mulatta GNL3L VGNC VGNC:73011
Bos taurus GNL3L VGNC VGNC:29474
Others GNL3L NCBI