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ASB7 - ankyrin repeat and SOCS box containing 7 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 140460

About ASB7

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:100,602,589-100,651,701 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 4.8), thyroid (RPKM 4.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four Other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ASB7 Products (2)

mRNA	Protein	Name
NM_024708.4	NP_078984.2	ankyrin repeat and SOCS box protein 7 isoform 1
NM_198243.3	NP_937886.1	ankyrin repeat and SOCS box protein 7 isoform 2

ASB7 Protein Structure

Ank_2

SOCS_box

0
100
200
300
318 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat and SOCS box protein 7	ASB-7

ASB7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ASB7	Q9H672	CCDC136	Homo sapiens	Q96JN2-2	Validated Y2H	25416956
Intra	ASB7	Q9H672	CCDC136	Homo sapiens	Q96JN2-2	Anti Tag CoIP	28514442
Intra	ASB7	Q9H672	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	16325183
Intra	ASB7	Q9H672	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	28514442
Intra	ASB7	Q9H672	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	33961781
Intra	ASB7	Q9H672	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	ASB7	Q9H672	HMBOX1	Homo sapiens	Q6NT76	Anti Tag CoIP	33961781
Intra	ASB7	Q9H672	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	25416956
Intra	ASB7	Q9H672	RNF7	Homo sapiens	Q9UBF6	Anti Tag CoIP	16325183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lipase Deficiency, Combined	Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency Lpl And Htgl Deficiency Lpl And Hl Deficiency Familial Lipase Maturation Factor 1 Deficiency Lipase Deficiency Combined Combined Lipase Deficiency Familial Lmf1 Deficiency CLD
Isolated Microphthalmia
Heinz Body Anemias	Heinz Body Anemia Heinz Body Anemias, Alpha- HEIBAN Anemia, Heinz Body Acquired Heinz Body Anemia
Short-Rib Thoracic Dysplasia 9 With Or Without Polydactyly	Conorenal Syndrome Saldino-Mainzer Syndrome SRTD9 Mainzer-Saldino Syndrome Mzsds Mainzer-Saldino Disease Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia, And Skeletal Dysplasia Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dysplasia Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dy Mainzer Saldino Syndrome Conorenal Dysplasia Mainzer-Saldino Chondrodysplasia Saldino-Mainzer Dysplasia Short-Rib Thoracic Dysplasia 9 Renal Dysplasia-Retinal Pigmentary Dystrophy-Cerebellar Ataxia-Skeletal Dysplasia Syndrome Mss Renal Dysplasia Retinal Pigmentary Dystrophy Cerebellar Ataxia And Skeletal Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01072	ASB7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ASB7	VGNC	VGNC:59963
Canis familiaris	ASB7	VGNC	VGNC:38167
Bos taurus	ASB7	VGNC	VGNC:26200
Rattus norvegicus	ASB7	RGD	RGD:1305154
Mus musculus	ASB7	MGD	MGI:2152835
Macaca mulatta	ASB7	VGNC	VGNC:69851
Others	ASB7	NCBI