RASGRP3 - RAS guanyl releasing protein 3 Gene

Also Known as GRP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25780

About RASGRP3

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:33,436,348-33,564,731 (from NCBI)

This gene has 18 transcripts (splice variants), 198 orthologues and 24 paralogues. Broad expression in lymph node (RPKM 8.7), appendix (RPKM 6.4) and 22 other tissues.

Summary

The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]

RASGRP3 Products (10)

mRNA Protein Name
NM_001139488.2 NP_001132960.1 ras guanyl-releasing protein 3 isoform 1
NM_001349975.2 NP_001336904.1 ras guanyl-releasing protein 3 isoform 1
NM_001349976.2 NP_001336905.1 ras guanyl-releasing protein 3 isoform 1
NM_001349977.2 NP_001336906.1 ras guanyl-releasing protein 3 isoform 1
NM_001349978.2 NP_001336907.1 ras guanyl-releasing protein 3 isoform 2
NM_001349979.2 NP_001336908.1 ras guanyl-releasing protein 3 isoform 2
NM_001349980.2 NP_001336909.1 ras guanyl-releasing protein 3 isoform 2
NM_001349981.2 NP_001336910.1 ras guanyl-releasing protein 3 isoform 2
NM_015376.3 NP_056191.1 ras guanyl-releasing protein 3 isoform 2
NM_170672.3 NP_733772.1 ras guanyl-releasing protein 3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
10934204 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASGRP3 Protein Structure

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (8 - 102)

RasGEF

RasGEF: RasGEF domain (151 - 331)

EF-hand_6

EF-hand_6: EF-hand domain (426 - 448)

EF-hand_5

EF-hand_5: EF hand (460 - 476)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (495 - 544)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
Protein Preferred Names Protein Names

ras guanyl-releasing protein 3

  • CalDAG-GEFIII

RASGRP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RASGRP3 Q8IV61 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
RASGRP3 Q8IV61 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
RASGRP3 Q8IV61 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
RASGRP3 Q8IV61 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
Intra
RASGRP3 Q8IV61 GET1 Homo sapiens O00258
Y2H Array
32296183
Intra
RASGRP3 Q8IV61 DYNLL2 Homo sapiens Q96FJ2
Validated Y2H
25416956
Intra
RASGRP3 Q8IV61 DYNLL2 Homo sapiens Q96FJ2
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lupus Erythematosus

  • Lupus

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus, Systemic

  • Subacute Cutaneous Lupus

  • Le - [Lupus Erythematosus]
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Melanoma, Uveal

  • Uveal Melanoma

  • Choroidal Melanoma

  • Melanoma Of Uvea

  • Iris Melanoma

  • Malignant Melanoma Of Choroid

  • Malignant Melanoma Of Iris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11695 RASGRP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123977 RasGRP3 ligand 1 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RASGRP3 VGNC VGNC:33749
Canis familiaris RASGRP3 VGNC VGNC:45373
Rattus norvegicus RASGRP3 RGD RGD:1304612
Felis catus RASGRP3 VGNC VGNC:64502
Macaca mulatta RASGRP3 VGNC VGNC:106206
Mus musculus RASGRP3 MGD MGI:3028579
Others RASGRP3 NCBI