XRN2 - 5'-3' exoribonuclease 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22803

About XRN2

Cytogenetic location: 20p11.22 Genomic coordinates (GRCh38): 20:21,303,331-21,389,825 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 21.1), thyroid (RPKM 20.8) and 25 other tissues.

Summary

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

XRN2 Products (2)

mRNA	Protein	Name
NM_001317960.1	NP_001304889.1	5'-3' exoribonuclease 2 isoform 1
NM_012255.5	NP_036387.2	5'-3' exoribonuclease 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-5'-RNA exonuclease activity	EXP EXP: Inferred from Experiment	23482395	GOA
enables 5'-3' exonuclease activity	IDA IDA: Inferred from direct assay	15565158	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15231747	GOA
enables transcription termination site sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21700224	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	10409438	GOA
involved in termination of RNA polymerase II transcription	IMP IMP: Inferred from mutant phenotype	15565158	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleolus	IDA IDA: Inferred from direct assay	12429849	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRN2 Protein Structure

XRN_N

0
200
400
600
800
950 a.a.

Protein Preferred Names	Protein Names
5'-3' exoribonuclease 2	DHM1-like protein

XRN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XRN2	Q9H0D6	CDKN2AIPNL	Homo sapiens	Q96HQ2	Anti Tag CoIP	34591612
Intra	XRN2	Q9H0D6	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	XRN2	Q9H0D6	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	XRN2	Q9H0D6	CDKN2AIP	Homo sapiens	Q9NXV6	Anti Tag CoIP	34591612
Intra	XRN2	Q9H0D6	DISC1	Homo sapiens	Q9NRI5	Y2H	17043677
Intra	XRN2	Q9H0D6	TARDBP	Homo sapiens	Q13148	Y2H	15231747
Intra	XRN2	Q9H0D6	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

XRN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84786	XRN2 Antibody (YA4483)	WB, IHC-P, ELISA	Human
HY-P84786A	XRN2 Antibody (YA4483)(PBS only)	WB, IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Amyotrophic Lateral Sclerosis 4, Juvenile	Amyotrophic Lateral Sclerosis Type 4 ALS4 Amyotrophic Lateral Sclerosis 4 Dhmn With Upper Motor Neuron Signs Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs Neuronopathy, Distal Hereditary Motor, With Pyramidal Features Als 4 Distal Hereditary Motor Neuropathy With Pyramidal Features Amyotrophic Lateral Sclerosis Juvenile 4 Neuronopathy Distal Hereditary Motor With Pyramidal Features Sclerosis, Lateral, Amyotrophic, Type Type 4
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2	Aoa2 Ataxia With Oculomotor Apraxia Type 2 Scar1 SCAN2 Ataxia-Oculomotor Apraxia 2 Ataxia-Ocular Apraxia 2 Ataxia-Oculomotor Apraxia Type 2 Scan 2 Spinocerebellar Ataxia With Axonal Neuropathy Type 2 Spinocerebellar Ataxia, Autosomal Recessive 1, Formerly Scar1, Formerly Autosomal Recessive Spinocerebellar Ataxia-1 Spinocerebellar Ataxia, Autosomal Recessive, 1 Ataxia-Ocular Apraxia-2 Spinocerebellar Ataxia, Autosomal Recessive 1
Corneal Dystrophy, Posterior Polymorphous, 1	Posterior Polymorphous Corneal Dystrophy Ppcd Maumenee Corneal Dystrophy Posterior Polymorphous Corneal Dystrophy 1 PPCD1 Corneal Dystrophy, Hereditary Polymorphous Posterior Corneal Endothelial Dystrophy 1, Autosomal Dominant Schlichting Dystrophy Ched1 Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly Ched1, Formerly Hereditary Polymorphus Posterior Corneal Dystrophy Posterior Polymorphous Dystrophy Hereditary Polymorphous Posterior Corneal Dystrophy Dystrophy, Corneal, Posterior Polymorphous Dystrophy, Corneal, Posterior Polymorphous, Type 1 Polymorphous Corneal Dystrophy Corneal Endothelial Dystrophy 2
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173593	Adenosine-3',5'-bisphosphate	Inhibitor	/	Unkown
HY-RS15903	XRN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20840	Xrn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27354	Xrn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	XRN2	VGNC	VGNC:78814
Rattus norvegicus	XRN2	RGD	RGD:1310218
Felis catus	XRN2	VGNC	VGNC:67123
Mus musculus	XRN2	MGD	MGI:894687
Canis familiaris	XRN2	VGNC	VGNC:48472
Bos taurus	XRN2	VGNC	VGNC:37009
Others	XRN2	NCBI