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TRIO - trio Rho guanine nucleotide exchange factor Gene

Also Known as tgat; MEBAS; MRD44; MRD63; ARHGEF23

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7204

About TRIO

Cytogenetic location: 5p15.2 Genomic coordinates (GRCh38): 5:14,143,342-14,510,204 (from NCBI)

This gene has 27 transcripts (splice variants), 226 orthologues, 22 paralogues and is associated with 4 phenotypes. Ubiquitous expression in brain (RPKM 8.0), spleen (RPKM 6.0) and 25 other tissues.

Summary

This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin Cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

TRIO Products (1)

mRNA	Protein	Name
NM_007118.4	NP_009049.2	triple functional domain protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17043677	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	32109419	GOA
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26858404	GOA
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26858404	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26858404	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26858404	GOA
is active in presynaptic active zone	IDA IDA: Inferred from direct assay	27907191	GOA
is active in presynaptic active zone	IMP IMP: Inferred from mutant phenotype	27907191	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIO Protein Structure

CRAL_TRIO_2

Spectrin

RhoGEF

SH3_1

RhoGEF

I-set

Pkinase

0
500
1000
1500
2000
2500
3097 a.a.

Protein Preferred Names	Protein Names
triple functional domain protein	PTPRF-interacting protein

TRIO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIO	O75962	DISC1	Homo sapiens	Q9NRI5	Y2H	17043677

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 44, With Microcephaly	MRD44 Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome Autosomal Dominant Non-Syndromic Intellectual Disability 44 Mental Retardation, Autosomal Dominant 44 Autosomal Dominant Intellectual Developmental Disorder 44 Autosomal Dominant Intellectual Developmental Disorder 44 With Microcephaly Autosomal Dominant Mental Retardation 44 Mental Retardation, Autosomal Dominant, Type 44
Intellectual Developmental Disorder, Autosomal Dominant 63, With Macrocephaly	MRD63 Mental Retardation, Autosomal Dominant 63, With Macrocephaly
Deafness, Autosomal Recessive 28	DFNB28 Autosomal Recessive Nonsyndromic Deafness 28 Autosomal Recessive Deafness 28 Deafness, Autosomal Recessive, 28 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 28 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 28 Deafness, Autosomal Recessive, Type 28
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Gastroesophageal Adenocarcinoma	Gastric And Esophageal Adenocarcinoma Gastro-Esophageal Adenocarcinoma
Loeys-Dietz Syndrome 2	LDS2 Aat3 Marfan Syndrome Type 2 Aortic Aneurysm, Familial Thoracic 3 Marfan Syndrome Type Ii Loeys-Dietz Syndrome Type 2 Mfs2 Marfan Syndrome, Type Ii, Formerly Familial Throacic Aortic Aneurysm 3 Familial Aortic Aneurysm Thoracic Type 3 Taad2 Thoracic Aortic Aneurysms And Dissection 2 Aneurysm, Aortic, Thoracic, Familial, Type 3 Loeys-Dietz Syndrome, Type 2
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS24288	Trio Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIO	MGD	MGI:1927230
Canis familiaris	TRIO	VGNC	VGNC:47842
Rattus norvegicus	TRIO	RGD	RGD:1308360
Bos taurus	TRIO	VGNC	VGNC:36356
Macaca mulatta	TRIO	VGNC	VGNC:84509
Others	TRIO	NCBI