Ndel1 - nudE neurodevelopment protein 1 like 1 Gene

Also Known as NUDEL; MITAP1; mNudel; mNudE-L; 2600006O07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83431

Summary

Enables identical protein binding activity and tubulin binding activity. Involved in several processes, including Insulin Receptor signaling pathway; lysosome localization; and regulation of plasma membrane bounded cell projection organization. Acts upstream of or within several processes, including Cytoskeleton organization; generation of neurons; and transport along microtubule. Located in several cellular components, including axon hillock; cytoskeleton; and synaptic vesicle. Part of microtubule associated complex. Is expressed in several structures, including central nervous system; craniocervical region bone; integumental system; metanephros; and sensory organ. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Ndel1 Products (3)

mRNA Protein Name
NM_001363304.1 NP_001350233.1 nuclear distribution protein nudE-like 1 isoform 2
NM_001363305.1 NP_001350234.1 nuclear distribution protein nudE-like 1 isoform 3
NM_023668.3 NP_076157.2 nuclear distribution protein nudE-like 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
18331715 MGI
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
18331715 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
17997972 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
11163259 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11231056 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of GTPase activity IDA
IDA: Inferred from direct assay
18331715 MGI
NOT involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20624590 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
18331715 MGI
acts upstream of or within central nervous system neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
15208636 MGI
acts upstream of or within centrosome localization IMP
IMP: Inferred from mutant phenotype
18331715 MGI
involved in cerebral cortex radially oriented cell migration IMP
IMP: Inferred from mutant phenotype
20624590 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
16107726 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
28057765 MGI
involved in lysosome localization IMP
IMP: Inferred from mutant phenotype
27777970 MGI
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: Inferred from genetic interaction
16107726 MGI
acts upstream of or within mitotic centrosome separation IGI
IGI: Inferred from genetic interaction
17060449 MGI
acts upstream of or within mitotic centrosome separation IMP
IMP: Inferred from mutant phenotype
17060449 MGI
acts upstream of or within neurofilament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15208636 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
16107726 MGI
acts upstream of or within neuron projection extension IGI
IGI: Inferred from genetic interaction
19668197 MGI
involved in positive regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
27777970 MGI
acts upstream of or within radial glia-guided pyramidal neuron migration IGI
IGI: Inferred from genetic interaction
16107726 MGI
involved in regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17825401 MGI
acts upstream of or within retrograde axonal transport IDA
IDA: Inferred from direct assay
11163259 MGI
acts upstream of or within vesicle transport along microtubule IGI
IGI: Inferred from genetic interaction
16107726 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
16203747 MGI
located in axon hillock IDA
IDA: Inferred from direct assay
19668197 MGI
located in cell leading edge IDA
IDA: Inferred from direct assay
18331715 MGI
located in centrosome IDA
IDA: Inferred from direct assay
11163259 MGI
part of microtubule associated complex IDA
IDA: Inferred from direct assay
11163259 MGI
located in microtubule organizing center IGI
IGI: Inferred from genetic interaction
19668197 MGI
located in neurofilament cytoskeleton IDA
IDA: Inferred from direct assay
15208636 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
18983980 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear distribution protein nudE-like 1

  • nuclear disribution gene E like

  • nuclear distribution gene E-like homolog 1

  • protein Nudel

Ndel1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ndel1 Q9ERR1 Ywhae Mus musculus P62259
Pull Down
12796778
Intra
Ndel1 Q9ERR1 Ywhae Mus musculus P62259
Anti Bait CoIP
12796778
Intra
Ndel1 Q9ERR1 PAFAH1B1 Homo sapiens P43034
Anti Tag CoIP
26496610
Intra
Ndel1 Q9ERR1 Pafah1b1 Mus musculus P63005
Y2H
11231056
Intra
Ndel1 Q9ERR1 Pafah1b1 Mus musculus P63005
Anti Bait CoIP
12796778
Intra
Ndel1 Q9ERR1 Pafah1b1 Mus musculus P63005
Pull Down
11231056
Intra
Ndel1 Q9ERR1 Ndel1 Mus musculus Q9ERR1
X-Ray Diffraction
17997972
Intra
Ndel1 Q9ERR1 PAFAH1B1 Homo sapiens P43034
Anti Bait CoIP
19927128
Intra
Ndel1 Q9ERR1 Ndel1 Mus musculus Q9ERR1
Solution Sedimentation
17997972
Intra
Ndel1 Q9ERR1 Ndel1 Mus musculus Q9ERR1
CD
17997972
Intra
Ndel1 Q9ERR1 Pafah1b1 Mus musculus P63005
Pull Down
17997972
Intra
Ndel1 Q9ERR1 Pafah1b1 Mus musculus P63005
EPR
17997972
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175496 Acid Ceramidase-IN-3 Inhibitor / Unkown
HY-RS09107 NDEL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndel1 NCBI NCBI:81565