CDX1 - caudal type homeobox 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1044

About CDX1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,166,778-150,184,558 (from NCBI)

This gene has 1 transcript (splice variant), 94 orthologues and 2 paralogues. Biased expression in colon (RPKM 56.3), small intestine (RPKM 34.1) and 2 other tissues.

Summary

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal Alkaline Phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]

CDX1 Products (1)

mRNA Protein Name
NM_001804.3 NP_001795.2 homeobox protein CDX-1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15774940 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15774940 GOA
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19059241 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
24623306 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15774940 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24623306 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDX1 Protein Structure

Caudal_act

Caudal_act: Caudal like protein activation region (13 - 146)

Homeobox

Homeobox: Homeobox domain (156 - 211)

  • 0
  • 100
  • 200
  • 265 a.a.
Protein Preferred Names Protein Names

homeobox protein CDX-1

  • caudal type homeo box transcription factor 1

CDX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDX1 P47902 CEBPA Homo sapiens P49715
Y2H
19059241
Cross: Cross-species interaction Intra: Intraspecies interaction

CDX1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82217 CDX1 Antibody (YA1962) WB, ICC/IF Human

Related Diseases

Diseases Alias
Esophagus Melanoma

  • Melanoma Of Esophagus

  • Melanoma Of Oesophagus

  • Oesophagus Melanoma

  • Esophageal Melanoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Bile Reflux
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Mesenchymal Chondrosarcoma

  • Chondrosarcoma, Mesenchymal

  • Chondrosarcoma Mesenchymal
Klippel-Feil Syndrome

  • Cervical Vertebral Fusion

  • Congenital Dystrophia Brevicollis

  • Cervical Fusion Syndrome

  • Klippel-Feil Deformity

  • Autosomal Dominant Klippel-Feil Syndrome

  • Congenital Synostosis Of Cervical Vertebrae

  • Klippel-Feil And Turner Syndrome

  • Klippel-Feil Deformity, Deafness And Facial Asymmetry

  • Klippel Feil Syndrome

  • Cervical Vertebral Fusion Syndrome

  • Dystrophia Brevicollis Congenita

  • Fusion Of Cervical Vertebrae

  • Kfs

  • Klippel-Feil Sequence

  • Vertebral Cervical Fusion Syndrome

  • Klippel-Feil Syndrome, Autosomal Dominant

  • Klippel-Feil Malformation

  • Isolated Klippel-Feil Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02429 CDX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CDX1 VGNC VGNC:110474
Bos taurus CDX1 VGNC VGNC:106683
Canis familiaris CDX1 VGNC VGNC:39084
Felis catus CDX1 VGNC VGNC:60722
Mus musculus CDX1 MGD MGI:88360
Rattus norvegicus CDX1 RGD RGD:621233
Others CDX1 NCBI