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Cat. No.: HY-W011927S

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4,4'-Sulfonyldiphenol-d₈

(Synonyms: Bisphenol S (4,4'-Sulfonyldiphenol)-d₈)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

4,4'-Sulfonyldiphenol-d₈ (Bisphenol S (4,4'-Sulfonyldiphenol)-d₈) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.

For research use only. We do not sell to patients.

Purity: 99.21%
CAS No.: 2483831-28-1
Formula: C₁₂H₂D₈O₄S
Molecular Weight:258.32

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

4,4'-Sulfonyldiphenol-d₈ Chemical Structure

CAS No.: 2483831-28-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Publications (1)
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Estrogen Receptor/ERR Isoforms :

All Histone Methyltransferase Isoforms :

All PI3K Isoforms :

All Akt Isoforms :

All mTOR Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2483831-28-1
Unlabeled Cas 80-09-1
Appearance Solid
Molecular Weight 258.32
Formula C₁₂H₂D₈O₄S
Color White to off-white
SMILES

O=S(C1=C([2H])C([2H])=C(C([2H])=C1[2H])O)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])O)=O
Synonyms

Bisphenol S (4,4'-Sulfonyldiphenol)-d₈
Shipping

Room temperature in continental US; may vary elsewhere.