TXNDC2 - thioredoxin domain containing 2 Gene

Also Known as SPTRX; SPTRX1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84203

Summary

Enables thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis and spermatogenesis. Predicted to act upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Restricted expression toward testis (RPKM 25.5).

TXNDC2 Products (2)

mRNA Protein Name
NM_001098529.2 NP_001091999.1 thioredoxin domain-containing protein 2 isoform 2
NM_032243.6 NP_115619.4 thioredoxin domain-containing protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables thioredoxin-disulfide reductase (NADPH) activity IDA
IDA: Inferred from direct assay
11399755 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11399755 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TXNDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TXNDC2 Q86VQ3 DDIT3 Homo sapiens P35638
Y2H Array
32296183
Intra
TXNDC2 Q86VQ3 DDIT3 Homo sapiens P35638
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15294 TXNDC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15289 TXNDC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15290 TXNDC12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15291 TXNDC15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15292 TXNDC16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15293 TXNDC17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17353 Txndc5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20658 Txndc15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20659 Txndc17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21267 Txndc12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23807 Txndc5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27169 Txndc15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27170 Txndc17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27785 Txndc12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown