2. Gene
  3. HNRNPL - heterogeneous nuclear ribonucleoprotein L Gene

HNRNPL - heterogeneous nuclear ribonucleoprotein L Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HNRPL; hnRNP-L; P/OKcl.14

Gene ID: 3191 | Gene type: protein coding

About HNRNPL

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,836,370-38,852,347 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 295 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 99.2), lymph node (RPKM 60.1) and 25 other tissues.

Summary

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HNRNPL Products(3)

mRNA Protein Name
NM_001005335.2 NP_001005335.1 heterogeneous nuclear ribonucleoprotein L isoform b
NM_001385651.1 NP_001372580.1 heterogeneous nuclear ribonucleoprotein L isoform c
NM_001533.3 NP_001524.2 heterogeneous nuclear ribonucleoprotein L isoform a

HNRNPL Protein Structure

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (120 - 174)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (211 - 268)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (400 - 454)

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  • 589 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein L

epididymis secretory sperm binding protein

Related Diseases

Diseases Alias
Alzheimer Disease 5

Ad5

Alzheimer'S Disease 5

Alzheimer Disease, Familial, 5

Alzheimer Disease-5

Alzheimer Disease, Familial 5

Alzheimer'S Disease 5, Late Onset

Alzheimer Disease, Familial, Type 5
Mouth Disease

Mouth Diseases

Mouth Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06274 HNRNPL Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HNRNPL MGD MGI:104816
Rattus norvegicus HNRNPL RGD RGD:71059
Macaca mulatta HNRNPL VGNC VGNC:81187
Bos taurus HNRNPL VGNC VGNC:54437
Felis catus HNRNPL VGNC VGNC:67610
Canis familiaris HNRNPL VGNC VGNC:54847