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NCKAP1 - NCK associated protein 1 Gene

Also Known as HEM2; NAP1; NAP125; p125Nap1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10787

About NCKAP1

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:182,909,115-183,038,457 (from NCBI)

This gene has 10 transcripts (splice variants), 226 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 62.7), brain (RPKM 61.6) and 24 other tissues.

Summary

Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]

NCKAP1 Products (2)

mRNA	Protein	Name
NM_013436.5	NP_038464.1	nck-associated protein 1 isoform 1
NM_205842.3	NP_995314.1	nck-associated protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11418237	GOA
contributes to small GTPase binding	IDA IDA: Inferred from direct assay	21107423	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Rac protein signal transduction	IDA IDA: Inferred from direct assay	21107423	GOA
involved in positive regulation of Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	21107423	GOA
involved in positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	21107423	GOA
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	18560548	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCAR complex	IDA IDA: Inferred from direct assay	21107423	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCKAP1 Protein Structure

Nckap1

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1128 a.a.

Protein Preferred Names	Protein Names
nck-associated protein 1	membrane-associated protein HEM-2

NCKAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCKAP1	Q9Y2A7	CYFIP1	Homo sapiens	Q7L576	Anti Tag CoIP	33961781
Intra	NCKAP1	Q9Y2A7	CYFIP1	Homo sapiens	Q7L576	Y2H	15296760
Intra	NCKAP1	Q9Y2A7	CYFIP1	Homo sapiens	Q7L576	Anti Tag CoIP	35271311
Intra	NCKAP1	Q9Y2A7	CYFIP1	Homo sapiens	Q7L576	Y2H	15294869
Intra	NCKAP1	Q9Y2A7	ABI1	Homo sapiens	Q8IZP0	Anti Bait CoIP	15048123
Intra	NCKAP1	Q9Y2A7	ABI1	Homo sapiens	Q8IZP0	Anti Tag CoIP	33961781
Intra	NCKAP1	Q9Y2A7	ABI1	Homo sapiens	Q8IZP0	CoIP	11418237
Intra	NCKAP1	Q9Y2A7	ABI1	Homo sapiens	Q8IZP0	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09082	NCKAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09083	NCKAP1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NCKAP1	VGNC	VGNC:43653
Rattus norvegicus	NCKAP1	RGD	RGD:61939
Bos taurus	NCKAP1	VGNC	VGNC:31915
Macaca mulatta	NCKAP1	VGNC	VGNC:75143
Mus musculus	NCKAP1	MGD	MGI:1355333
Felis catus	NCKAP1	VGNC	VGNC:68429
Others	NCKAP1	NCBI