2. Gene
  3. ARPC4 - actin related protein 2/3 complex subunit 4 Gene

ARPC4 - actin related protein 2/3 complex subunit 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARC20; DEVLO; P20-ARC

Gene ID: 10093 | Gene type: protein coding

About ARPC4

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,792,518-9,807,101 (from NCBI)

This gene has 8 transcripts (splice variants), 269 orthologues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 63.0), appendix (RPKM 61.6) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]

ARPC4 Products(4)

mRNA Protein Name
NM_001024959.3 NP_001020130.1 actin-related protein 2月3日 complex subunit 4 isoform b
NM_001024960.3 NP_001020131.1 actin-related protein 2月3日 complex subunit 4 isoform b
NM_001198780.3 NP_001185709.1 actin-related protein 2月3日 complex subunit 4 isoform c
NM_005718.5 NP_005709.1 actin-related protein 2月3日 complex subunit 4 isoform a

ARPC4 Protein Structure

ARPC4

ARPC4: ARP2/3 complex 20 kDa subunit (ARPC4) (1 - 168)

  • 0
  • 100
  • 168 a.a.
Protein Preferred Names Protein Names

actin-related protein 2/3 complex subunit 4

actin related protein 2/3 complex, subunit 4, 20kDa

Related Diseases

Diseases Alias
Patellar Tendinitis

Patellar Tendonitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01021 ARPC4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARPC4 RGD RGD:1310096
Felis catus ARPC4 VGNC VGNC:69349
Canis familiaris ARPC4 VGNC VGNC:54574
Mus musculus ARPC4 MGD MGI:1915339