ARPC5L - actin related protein 2/3 complex subunit 5 like Gene

Also Known as ARC16-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81873

About ARPC5L

This gene has 3 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 7.3) and 25 other tissues.

Summary

Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in extracellular exosome and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

ARPC5L Products (1)

mRNA Protein Name
NM_030978.3 NP_112240.1 actin-related protein 2月3日 complex subunit 5-like protein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPC5L Protein Structure

P16-Arc

P16-Arc: ARP2/3 complex 16 kDa subunit (p16-Arc) (9 - 153)

  • 0
  • 100
  • 153 a.a.
Protein Preferred Names Protein Names

actin-related protein 2/3 complex subunit 5-like protein

  • arp2/3 complex 16 kDa subunit 2

ARPC5L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARPC5L Q9BPX5 ARPC4 Homo sapiens P59998
Anti Tag CoIP
26655834
Intra
ARPC5L Q9BPX5 ARPC4 Homo sapiens P59998
Crosslink
30021884
Intra
ARPC5L Q9BPX5 ARPC4 Homo sapiens P59998
Y2H Pooling
16169070
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lissencephaly 3

  • LIS3

  • Lissencephaly Due To Tuba1a Mutation

  • Lissencephaly Type 3

  • Lissencephaly, Type 3
Leopard Syndrome 1

  • LPRD1

  • Noonan Syndrome With Multiple Lentigines 1

  • Lentiginosis, Cardiomyopathic

  • Multiple Lentigines Syndrome

  • Leopard Syndrome, Type 1

  • Leopard Syndrome

  • Multiple Lentigines
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01023 ARPC5L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARPC5L VGNC VGNC:38132
Macaca mulatta ARPC5L VGNC VGNC:103242
Mus musculus ARPC5L MGD MGI:1921442
Bos taurus ARPC5L VGNC VGNC:26166
Rattus norvegicus ARPC5L RGD RGD:1308867
Others ARPC5L NCBI