2. Gene
  3. METTL21A - methyltransferase 21A, HSPA lysine Gene

METTL21A - methyltransferase 21A, HSPA lysine Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FAM119A; HCA557b; HSPA-KMT

Gene ID: 151194 | Gene type: protein coding

About METTL21A

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:207,580,635-207,626,053 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 1.8), spleen (RPKM 1.7) and 25 other tissues.

Summary

Enables ATPase binding activity; HSP70 protein binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL21A Products(26)

mRNA Protein Name
NM_001127395.5 NP_001120867.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001308021.3 NP_001294950.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330130.2 NP_001317059.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001330131.2 NP_001317060.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330132.3 NP_001317061.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330133.3 NP_001317062.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330134.2 NP_001317063.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001330135.2 NP_001317064.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330136.3 NP_001317065.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330137.2 NP_001317066.1 protein N-lysine methyltransferase METTL21A isoform 4
NM_001388427.1 NP_001375356.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001388439.2 NP_001375368.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393563.1 NP_001380492.1 protein N-lysine methyltransferase METTL21A isoform 5
NM_001393564.1 NP_001380493.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393565.1 NP_001380494.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393566.1 NP_001380495.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393567.1 NP_001380496.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393568.1 NP_001380497.1 protein N-lysine methyltransferase METTL21A isoform 6
NM_001393569.1 NP_001380498.1 protein N-lysine methyltransferase METTL21A isoform 7
NM_001393570.1 NP_001380499.1 protein N-lysine methyltransferase METTL21A isoform 7
NM_001393571.1 NP_001380500.1 protein N-lysine methyltransferase METTL21A isoform 8
NM_001393572.1 NP_001380501.1 protein N-lysine methyltransferase METTL21A isoform 8
NM_001393573.1 NP_001380502.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001393574.1 NP_001380503.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001393575.1 NP_001380504.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_145280.7 NP_660323.3 protein N-lysine methyltransferase METTL21A isoform 1

METTL21A Protein Structure

Methyltransf_16

Methyltransf_16: Lysine methyltransferase (27 - 189)

  • 0
  • 100
  • 200
  • 218 a.a.
Protein Preferred Names Protein Names

protein N-lysine methyltransferase METTL21A

HSPA lysine methyltransferase

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 2a

Pontocerebellar Hypoplasia Type 2a

PCH2A

Pch2

Pontocerebellar Hypoplasia With Progressive Cerebral Atrophy

Volendam Neurodegenerative Disease

Pontocerebellar Hypoplasia 2a

Hypoplasia, Pontocerebellar, Type 2a
Malignant Ovarian Cyst
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08360 METTL21A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta METTL21A VGNC VGNC:74625
Mus musculus METTL21A MGD MGI:1914349
Rattus norvegicus METTL21A RGD RGD:7651604
Bos taurus METTL21A VGNC VGNC:31406
Felis catus METTL21A VGNC VGNC:80279
Canis familiaris METTL21A VGNC VGNC:57396