METTL21A - methyltransferase 21A, HSPA lysine Gene

Also Known as FAM119A; HCA557b; HSPA-KMT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151194

About METTL21A

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:207,580,635-207,626,053 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 1.8), spleen (RPKM 1.7) and 25 other tissues.

Summary

Enables ATPase binding activity; HSP70 protein binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL21A Products (26)

mRNA Protein Name
NM_001127395.5 NP_001120867.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001308021.3 NP_001294950.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330130.2 NP_001317059.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001330131.2 NP_001317060.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330132.3 NP_001317061.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330133.3 NP_001317062.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330134.2 NP_001317063.1 protein N-lysine methyltransferase METTL21A isoform 1
NM_001330135.2 NP_001317064.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001330136.3 NP_001317065.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001330137.2 NP_001317066.1 protein N-lysine methyltransferase METTL21A isoform 4
NM_001388427.1 NP_001375356.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001388439.2 NP_001375368.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393563.1 NP_001380492.1 protein N-lysine methyltransferase METTL21A isoform 5
NM_001393564.1 NP_001380493.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393565.1 NP_001380494.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393566.1 NP_001380495.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393567.1 NP_001380496.1 protein N-lysine methyltransferase METTL21A isoform 2
NM_001393568.1 NP_001380497.1 protein N-lysine methyltransferase METTL21A isoform 6
NM_001393569.1 NP_001380498.1 protein N-lysine methyltransferase METTL21A isoform 7
NM_001393570.1 NP_001380499.1 protein N-lysine methyltransferase METTL21A isoform 7
NM_001393571.1 NP_001380500.1 protein N-lysine methyltransferase METTL21A isoform 8
NM_001393572.1 NP_001380501.1 protein N-lysine methyltransferase METTL21A isoform 8
NM_001393573.1 NP_001380502.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001393574.1 NP_001380503.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_001393575.1 NP_001380504.1 protein N-lysine methyltransferase METTL21A isoform 3
NM_145280.7 NP_660323.3 protein N-lysine methyltransferase METTL21A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
23921388 GOA
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
23921388 GOA
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
23349634 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables protein methyltransferase activity IDA
IDA: Inferred from direct assay
23349634 GOA
enables protein-lysine N-methyltransferase activity IDA
IDA: Inferred from direct assay
22948820 GOA
Biological Process GO Annotation Evidence References Source
involved in peptidyl-lysine methylation IDA
IDA: Inferred from direct assay
23921388 GOA
involved in protein methylation IDA
IDA: Inferred from direct assay
22948820 GOA
NOT involved in regulation of ATP-dependent activity IDA
IDA: Inferred from direct assay
23921388 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
23349634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL21A Protein Structure

Methyltransf_16

Methyltransf_16: Lysine methyltransferase (27 - 189)

  • 0
  • 100
  • 200
  • 218 a.a.
Protein Preferred Names Protein Names

protein N-lysine methyltransferase METTL21A

  • HSPA lysine methyltransferase

METTL21A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
METTL21A Q8WXB1 MSRB3 Homo sapiens Q8IXL7-2
Y2H Array
32296183
Intra
METTL21A Q8WXB1 MSRB3 Homo sapiens Q8IXL7-2
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
METTL21A Q8WXB1 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
METTL21A Q8WXB1 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
METTL21A Q8WXB1 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
METTL21A Q8WXB1 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 ARPC4 Homo sapiens P59998
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 ARPC4 Homo sapiens P59998
Y2H Array
32296183
Intra
METTL21A Q8WXB1 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
METTL21A Q8WXB1 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra
METTL21A Q8WXB1 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
METTL21A Q8WXB1 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
METTL21A Q8WXB1 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
METTL21A Q8WXB1 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
METTL21A Q8WXB1 FAM200C Homo sapiens Q8IZ13
Y2H
21516116
Intra
METTL21A Q8WXB1 FAM200C Homo sapiens Q8IZ13
Y2H Array
31515488
Intra
METTL21A Q8WXB1 FAM200C Homo sapiens Q8IZ13
Y2H Prey Pooling
32296183
Intra
METTL21A Q8WXB1 FAM200C Homo sapiens Q8IZ13
Y2H Array
32296183
Intra
METTL21A Q8WXB1 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra
METTL21A Q8WXB1 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra
METTL21A Q8WXB1 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
Intra
METTL21A Q8WXB1 ATRIP Homo sapiens Q8WXE1
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 2a

  • Pontocerebellar Hypoplasia Type 2a

  • PCH2A

  • Pch2

  • Pontocerebellar Hypoplasia With Progressive Cerebral Atrophy

  • Volendam Neurodegenerative Disease

  • Pontocerebellar Hypoplasia 2a

  • Hypoplasia, Pontocerebellar, Type 2a
Malignant Ovarian Cyst
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183602 FRC-303 Inhibitor / Unkown
HY-183603 FRC-222 Inhibitor / Unkown
HY-RS08360 METTL21A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta METTL21A VGNC VGNC:74625
Mus musculus METTL21A MGD MGI:1914349
Rattus norvegicus METTL21A RGD RGD:7651604
Bos taurus METTL21A VGNC VGNC:31406
Felis catus METTL21A VGNC VGNC:80279
Canis familiaris METTL21A VGNC VGNC:57396
Others METTL21A NCBI