ARPC3 - actin related protein 2/3 complex subunit 3 Gene

Also Known as ARC21; p21-Arc

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10094

About ARPC3

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,434,823-110,450,337 (from NCBI)

This gene has 9 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in lymph node (RPKM 232.8), bone marrow (RPKM 231.9) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

ARPC3 Products (2)

mRNA Protein Name
NM_001287222.2 NP_001274151.1 actin-related protein 2/3 complex subunit 3 isoform 2
NM_001278556.2 NP_001265485.1 actin-related protein 2/3 complex subunit 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to actin filament binding IDA
IDA: Inferred from direct assay
11741539 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11162547 GOA
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
11741539 GOA
Biological Process GO Annotation Evidence References Source
involved in Arp2/3 complex-mediated actin nucleation IDA
IDA: Inferred from direct assay
11741539 GOA
Cellular Component GO Annotation Evidence References Source
part of Arp2/3 protein complex IDA
IDA: Inferred from direct assay
11741539 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
9230079 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPC3 Protein Structure

P21-Arc

P21-Arc: ARP2/3 complex ARPC3 (21 kDa) subunit (1 - 173)

  • 0
  • 100
  • 178 a.a.
Protein Preferred Names Protein Names

actin-related protein 2/3 complex subunit 3

  • ARP2/3 protein complex subunit p21

  • actin related protein 2/3 complex, subunit 3, 21kDa

  • arp2/3 complex 21 kDa subunit

ARPC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARPC3 O15145 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
ARPC3 O15145 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
ARPC3 O15145 DUSP29 Homo sapiens Q68J44
Validated Y2H
32296183
Intra
ARPC3 O15145 DUSP29 Homo sapiens Q68J44
Y2H Array
32296183
Intra
ARPC3 O15145 DUSP29 Homo sapiens Q68J44
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 TARS3 Homo sapiens A2RTX5
Y2H Array
32296183
Intra
ARPC3 O15145 TARS3 Homo sapiens A2RTX5
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 RBBP8NL Homo sapiens Q8NC74
Y2H Array
32296183
Intra
ARPC3 O15145 RBBP8NL Homo sapiens Q8NC74
Validated Y2H
32296183
Intra
ARPC3 O15145 RBBP8NL Homo sapiens Q8NC74
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 POU2F1 Homo sapiens P14859-6
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 POU2F1 Homo sapiens P14859-6
Validated Y2H
32296183
Intra
ARPC3 O15145 POU2F1 Homo sapiens P14859-6
Y2H Array
32296183
Intra
ARPC3 O15145 SYBU Homo sapiens Q9NX95-5
Validated Y2H
32296183
Intra
ARPC3 O15145 SYBU Homo sapiens Q9NX95-5
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 SYBU Homo sapiens Q9NX95-5
Y2H Array
32296183
Intra
ARPC3 O15145 LATS1 Homo sapiens O95835-2
Y2H Array
32296183
Intra
ARPC3 O15145 LATS1 Homo sapiens O95835-2
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 LATS1 Homo sapiens O95835-2
Validated Y2H
32296183
Cross
ARPC3 O15145 N SARS-CoV-2 P0DTC9
Y2H Array
36217030
Intra
ARPC3 O15145 CCR10 Homo sapiens P46092
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 CCR10 Homo sapiens P46092
Validated Y2H
32296183
Intra
ARPC3 O15145 CCR10 Homo sapiens P46092
Y2H Array
32296183
Intra
ARPC3 O15145 ARPC4 Homo sapiens P59998
Anti Tag CoIP
33961781
Intra
ARPC3 O15145 ARPC4 Homo sapiens P59998
Anti Tag CoIP
35271311
Intra
ARPC3 O15145 ARPC4 Homo sapiens P59998
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 ARPC4 Homo sapiens P59998
Validated Y2H
32296183
Intra
ARPC3 O15145 ARPC4 Homo sapiens P59998
Y2H Array
32296183
Intra
ARPC3 O15145 ZNF576 Homo sapiens Q9H609
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 ZNF576 Homo sapiens Q9H609
Validated Y2H
32296183
Intra
ARPC3 O15145 ZNF576 Homo sapiens Q9H609
Y2H Array
32296183
Intra
ARPC3 O15145 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
ARPC3 O15145 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
ARPC3 O15145 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ARPC3 O15145 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
ARPC3 O15145 NRIP1 Homo sapiens P48552
Validated Y2H
25416956
Intra
ARPC3 O15145 FAM9A Homo sapiens Q8IZU1
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 FAM9A Homo sapiens Q8IZU1
Validated Y2H
32296183
Intra
ARPC3 O15145 FAM9A Homo sapiens Q8IZU1
Y2H Array
32296183
Intra
ARPC3 O15145 HOXA3 Homo sapiens O43365
Y2H Prey Pooling
25416956
Intra
ARPC3 O15145 HOXA3 Homo sapiens O43365
Y2H Prey Pooling
32296183
Intra
ARPC3 O15145 HOXA3 Homo sapiens O43365
Validated Y2H
32296183
Intra
ARPC3 O15145 HOXA3 Homo sapiens O43365
Y2H Array
32296183
Intra
ARPC3 O15145 WASL Homo sapiens O00401
Validated Y2H
25416956
Intra
ARPC3 O15145 WASL Homo sapiens O00401
Y2H Array
32296183
Intra
ARPC3 O15145 WASL Homo sapiens O00401
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Porokeratosis

  • Disseminated Superficial Actinic Porokeratosis

  • Dsap

  • Porokeratosis Of Mibelli

  • Porokeratosis, Disseminated Superficial Actinic

  • Porokeratosis, Disseminated Superficial Actinic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01018 ARPC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01019 Arpc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01020 Arpc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARPC3 VGNC VGNC:99890
Rattus norvegicus ARPC3 RGD RGD:1311985
Bos taurus ARPC3 VGNC VGNC:53890
Mus musculus ARPC3 MGD MGI:1928375
Others ARPC3 NCBI