HOXA3 - homeobox A3 Gene

Also Known as HOX1; HOX1E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3200

About HOXA3

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,107,010-27,152,583 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 42 paralogues. Broad expression in kidney (RPKM 1.8), fat (RPKM 1.4) and 17 other tissues.

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HOXA3 Products (14)

mRNA Protein Name
NM_001384335.1 NP_001371264.1 homeobox protein Hox-A3
NM_001384336.1 NP_001371265.1 homeobox protein Hox-A3
NM_001384337.1 NP_001371266.1 homeobox protein Hox-A3
NM_001384338.1 NP_001371267.1 homeobox protein Hox-A3
NM_001384339.1 NP_001371268.1 homeobox protein Hox-A3
NM_001384340.1 NP_001371269.1 homeobox protein Hox-A3
NM_001384341.1 NP_001371270.1 homeobox protein Hox-A3
NM_001384342.1 NP_001371271.1 homeobox protein Hox-A3
NM_001384343.1 NP_001371272.1 homeobox protein Hox-A3
NM_001384344.1 NP_001371273.1 homeobox protein Hox-A3
NM_001384345.1 NP_001371274.1 homeobox protein Hox-A3
NM_001384346.1 NP_001371275.1 homeobox protein Hox-A3
NM_030661.5 NP_109377.1 homeobox protein Hox-A3
NM_153631.3 NP_705895.1 homeobox protein Hox-A3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IEP
IEP: Inferred from expression pattern
17972163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXA3 Protein Structure

Homeobox

Homeobox: Homeobox domain (192 - 248)

DUF4074

DUF4074: Domain of unknown function (DUF4074) (376 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 443 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-A3

  • Hox-1.5-like protein

HOXA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HOXA3 O43365 BDNF Homo sapiens P23560-2
Y2H Pooling
32814053
Intra
HOXA3 O43365 BDNF Homo sapiens P23560-2
Validated Y2H
32814053
Intra
HOXA3 O43365 BDNF Homo sapiens P23560-2
Y2H Array
32814053
Intra
HOXA3 O43365 ARPC3 Homo sapiens O15145
Validated Y2H
25416956
Intra
HOXA3 O43365 ARPC3 Homo sapiens O15145
Y2H Array
25416956
Intra
HOXA3 O43365 SEC23B Homo sapiens Q15437
Y2H
21516116
Intra
HOXA3 O43365 SEC23B Homo sapiens Q15437
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Penile Cancer

  • Penis Carcinoma

  • Carcinoma Of Penis

  • Penile Neoplasm

  • Penile Carcinoma

  • Penile Neoplasms

  • Malignant Neoplasm Of Penis

  • Ca Penis

  • Malignant Neoplasm Of Body Of Penis

  • Malignant Penile Tumor

  • Penile Ca
T-Cell Immunodeficiency With Thymic Aplasia

  • Nezelof Syndrome

  • T-Lymphocyte Deficiency

  • TIDTA

  • Immune Defect Due To Absence Of Thymus

  • Thymic Aplasia

  • Nezelof'S Syndrome

  • Thymic Dysplasia With Normal Immunoglobulins

  • Thymic Aplasia Syndrome

  • T-Lymphocyte Immunodeficiency
Ectopic Thymus
Thyroid Malformation
Hand-Foot-Genital Syndrome

  • Hand-Foot-Uterus Syndrome

  • Hfgs

  • Hfg Syndrome

  • Hfu Syndrome

  • HFG

  • Hfu

  • Hand Foot Uterus Syndrome

  • Hand Foot Genital Syndrome
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06298 HOXA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22558 Hoxa3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29078 Hoxa3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HOXA3 VGNC VGNC:73502
Felis catus HOXA3 VGNC VGNC:67619
Mus musculus HOXA3 MGD MGI:96175
Rattus norvegicus HOXA3 RGD RGD:1561431
Bos taurus HOXA3 VGNC VGNC:29911
Canis familiaris HOXA3 VGNC VGNC:41747
Others HOXA3 NCBI