2. PROTAC Protein Tyrosine Kinase/RTK
  3. Molecular Glues Src
  4. MRT-10350

MRT-10350 (Compound 2) is a cereblon-based HCK molecular glue degrader. MRT-10350 can be used for cancers like chronic myeloid leukemia and HIV-1 infections research.

For research use only. We do not sell to patients.

MRT-10350

MRT-10350 Chemical Structure

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5 mg In-stock
10 mg In-stock
25 mg In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

MRT-10350 Related Antibodies

Top Publications Citing Use of Products

View All Src Isoform Specific Products:

View All Isoforms
Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MRT-10350 (Compound 2) is a cereblon-based HCK molecular glue degrader. MRT-10350 can be used for cancers like chronic myeloid leukemia and HIV-1 infections research[1].

IC50 & Target[1]

Hck

 

Molecular Weight

494.56

Formula

C25H26N4O5S
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1(C2=CC=C(SC)C=C2)COCC1)NC3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4)=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (202.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0220 mL 10.1100 mL 20.2200 mL
5 mM 0.4044 mL 2.0220 mL 4.0440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0220 mL 10.1100 mL 20.2200 mL 50.5500 mL
5 mM 0.4044 mL 2.0220 mL 4.0440 mL 10.1100 mL
10 mM 0.2022 mL 1.0110 mL 2.0220 mL 5.0550 mL
15 mM 0.1348 mL 0.6740 mL 1.3480 mL 3.3700 mL
20 mM 0.1011 mL 0.5055 mL 1.0110 mL 2.5275 mL
25 mM 0.0809 mL 0.4044 mL 0.8088 mL 2.0220 mL
30 mM 0.0674 mL 0.3370 mL 0.6740 mL 1.6850 mL
40 mM 0.0505 mL 0.2527 mL 0.5055 mL 1.2637 mL
50 mM 0.0404 mL 0.2022 mL 0.4044 mL 1.0110 mL
60 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8425 mL
80 mM 0.0253 mL 0.1264 mL 0.2527 mL 0.6319 mL
100 mM 0.0202 mL 0.1011 mL 0.2022 mL 0.5055 mL
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MRT-10350 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRT-10350MRT10350MRT 10350Molecular GluesSrcMolecular glue degraderCereblonHCKCAL51 cellsHEK293T cellsChronic myeloid leukemiaHIV-1 infectionsInhibitorinhibitorinhibit

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