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Cat. No.: HY-175560

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SOS1-IN-22

SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC₅₀ value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma.

For research use only. We do not sell to patients.

CAS No.: 3092445-74-1
Formula: C₂₄H₂₉F₃N₄O₂
Molecular Weight:462.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SOS1-IN-22 Chemical Structure

CAS No.: 3092445-74-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

SOS1-IN-22 (Compound A15f) (72 h) shows proliferation-inhibitory activity with an IC₅₀ of 1.03 μM in K562 cells^[1].
SOS1-IN-22 (0-10000 nM) inhibits KRAS-G12C/SOS1 complex formation^[1].
SOS1-IN-22 (0-300 nM, 2 h) dose-dependently decreases pERK levels in K562 cells^[1].
SOS1-IN-22 (1-10 nM, 2 h) significantly enhances suppression of pERK expression combined within AMG510 (HY-114277) (20 nM) in MIAPaCa-2 cells^[1].
SOS1-IN-22 (0.0001-10 μM, 72 h) does not exhibit significant cytotoxicity in HL-7702 and 5k cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MIAPaCa-2 cells
Concentration:

1 and 10 μM
Incubation Time:

2 h, combined within AMG510 (HY-114277) (20 nM)
Result:

Decreased pERK levels.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-t	F	CL
Mice^[1]	10 mg/kg	p.o.	0.681 h	141 ng/mL	178 ng·h/mL	8.47 %	/
Mice^[1]	2 mg/kg	i.v.	0.364 h	1096 ng/mL	424 ng·h/mL	/	78.5 mL/min/kg

Chemical Information

CAS No. 3092445-74-1
Molecular Weight 462.51
Formula C₂₄H₂₉F₃N₄O₂
SMILES

O=C1C(C)(C)C2=NC(C)=NC(N[C@H](C)C3=CC=CC(C(F)F)=C3F)=C2CN1C4CCOCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Development and biological evaluation of novel SOS1 inhibitors featuring 5,8-dihydropyrido[4,3-d]pyrimidin-7(6H)-one scaffold. Bioorg Med Chem Lett. 2025 Dec 1;128:130344. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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