3092445-74-1
Chemical Structure
SOS1-IN-22
- CAS No.: 3092445-74-1
- Formula:C24H29F3N4O2
- Molecular Weight:462.51
IUPAC Name: (R)-4-((1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2,8,8-trimethyl-6-(tetrahydro-2H-pyran-4-yl)-5,8-dihydropyrido[4,3-d]pyrimidin-7(6H)-one
InChIKey: MEKSGFXJXWABNP-CYBMUJFWSA-N
SMILES: O=C1C(C)(C)C2=NC(C)=NC(N[C@H](C)C3=CC=CC(C(F)F)=C3F)=C2CN1C4CCOCC4
Biological Activity: SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC50 value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma[1].
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SOS1-IN-22 | SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC50 value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma. | |||||||||||||||||||||
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