(4S)-PROTAC SOS1 degrader-1 diTFA
Based on 1 Customer Validation
(4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 (diTFA) decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 (diTFA) significantly inhibits the tumor growth in vivo.
(Pink: SOS1 ligand (HY-111671); Blue: VHL ligand (HY-184855); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.09%
- Formula: C61H78ClF7N10O8S
- Molecular Weight:1279.84
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 1279.84
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Formula C61H78ClF7N10O8S
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Color White to off-white
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SMILES
O=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)CCCCCCCCN4CCN(CC4)C5=C6N=C(N7CC8(CNC8)C7)N(CC9=CC(C)=C(F)C(C)=C9)C6=CC(Cl)=C5.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (78.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.7813 mL | 3.9067 mL | 7.8135 mL | 19.5337 mL |
| 5 mM | 0.1563 mL | 0.7813 mL | 1.5627 mL | 3.9067 mL | |
| 10 mM | 0.0781 mL | 0.3907 mL | 0.7813 mL | 1.9534 mL | |
| 15 mM | 0.0521 mL | 0.2604 mL | 0.5209 mL | 1.3022 mL | |
| 20 mM | 0.0391 mL | 0.1953 mL | 0.3907 mL | 0.9767 mL | |
| 25 mM | 0.0313 mL | 0.1563 mL | 0.3125 mL | 0.7813 mL | |
| 30 mM | 0.0260 mL | 0.1302 mL | 0.2604 mL | 0.6511 mL | |
| 40 mM | 0.0195 mL | 0.0977 mL | 0.1953 mL | 0.4883 mL | |
| 50 mM | 0.0156 mL | 0.0781 mL | 0.1563 mL | 0.3907 mL | |
| 60 mM | 0.0130 mL | 0.0651 mL | 0.1302 mL | 0.3256 mL |
(4S)-PROTAC SOS1 degrader-1 diTFA Related Classifications
HY-144657A Related Classifications
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