country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184855

Copy Link Print Information

(S,S,S,S)-AHPC-Me

(S,S,S,S)-AHPC-Me is an E3 ligase ligand that can be used in research related to PROTAC synthesis, such as serving as the E3 ligase ligand for (4S)-PROTAC SOS1 degrader-1 (HY-144657).

For research use only. We do not sell to patients.

Formula: C₂₃H₃₂N₄O₃S
Molecular Weight:444.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S,S,S,S)-AHPC-Me Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(S,S,S,S)-AHPC-Me is an E3 ligase ligand that can be used in research related to PROTAC synthesis, such as serving as the E3 ligase ligand for (4S)-PROTAC SOS1 degrader-1 (HY-144657)^[1].

IC₅₀ & Target^[1]

VHL

All Ligands for E3 Ligase Isoforms :

In Vitro

(S,S,S,S)-AHPC-Me serves as the E3 ligase ligand for (4S)-PROTAC SOS1 degrader-1 (HY-144657), a potent PROTAC SOS1 degrader that reduces the expression levels of pERK and RAS-GTP in a dose-dependent manner and significantly inhibits tumor growth in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 444.59
Formula C₂₃H₃₂N₄O₃S
SMILES

N[C@@H](C(C)(C)C)C(N1C[C@@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou C, et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. Journal of medicinal chemistry. 2022 Mar 10;65(5):3923-3942. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

(S,S,S,S)-AHPC-Me

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(S,S,S,S)-AHPC-Me Related Classifications

HY-184855 Related Classifications