KRAS-IN-56
KRAS-IN-56 (Compound 18) is a KRAS inhibitor with an EC50 of 33 μM. KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1. KRAS-IN-56 induces a decrease in p-ERK levels. KRAS-IN-56 can be used in research related to lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 2375482-34-9
- Formula: C19H19N3O2
- Molecular Weight:321.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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K-RAS 33 μM (EC50) |
KRAS-IN-56 binds to the purified GCP-KRASG12D protein, with a measured Kd value of 20 μM via ITC[1].
KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1 in a biochemical assay, with an EC50 of 33 μM[1].
KRAS-IN-56 (10-8-10-4 M; 2 h) induces a dose-dependent decrease in pERK levels in NCI-H358 KRASG12C mutant lung cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2375482-34-9
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Molecular Weight 321.37
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Formula C19H19N3O2
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SMILES
CN(C)CC1=C([C@@H]2C3=CC(O)=CC=C3C(N2)=O)C4=CC=CC=C4N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS-IN-56 Related Classifications
HY-182411 Related Classifications
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