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Art. -Nr.: HY-163582

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PROTAC SOS1 degrader-7

PROTAC SOS1 degrader-7 (Example 15) is a PROTAC degrader that targets SOS1 protein degradation by recruiting cereblon. PROTAC SOS1 degrader-7 is applicable to research on the SOS1-RAS signaling pathway and tumors associated with KRAS mutations.
(Pink: SOS1 ligand (HY-163583); Blue: Cereblon ligand (HY-W454906); Black: linker (HY-163584)).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3036155-26-4
Formel: C₅₁H₆₄F₂N₁₀O₄
Molecular Weight:919.12

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PROTAC SOS1 degrader-7 Chemical Structure

CAS. Nr.: 3036155-26-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC SOS1 degrader-7 (Example 15) is a PROTAC degrader that targets SOS1 protein degradation by recruiting cereblon. PROTAC SOS1 degrader-7 is applicable to research on the SOS1-RAS signaling pathway and tumors associated with KRAS mutations^[1]. (Pink: SOS1 ligand (HY-163583); Blue: Cereblon ligand (HY-W454906); Black: linker (HY-163584)).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle Ras Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-cancer

PROTAC SOS1 degrader-7 (Example 15) (0.04-10000 nM) inhibits the KRAS G12C:SOS1 interaction, with an IC₅₀ of Grade B, namely 15 nM < IC₅₀ ≤ 30 nM^[1].
PROTAC SOS1 degrader-7 (0.03-3000 nM; 24 h) induces SOS1 protein degradation in KRAS G12C-mutated NCI-H358 cells, with a DC₅₀ of Grade A (i.e., DC₅₀ ≤ 50 nM) and a D_max of Grade A (i.e., 80% ≤ D_max ≤ 100%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3036155-26-4
Molecular Weight 919.12
Formel C₅₁H₆₄F₂N₁₀O₄
SMILES

CC1=NN=C(C2=C1C=NC(N3CCN(CC3)C(C4CCN(CC4)CC5CCC6(CCN(CC6)C(C7=CC(N8CCC(NC8=O)=O)=C(C=C7)C)=O)CC5)=O)=C2)N[C@@H](C9=CC=CC(C(F)F)=C9C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhengqing Ye, et al. Sos1 protein degradation agent and use thereof. WO2024083257A1.2024-04-25.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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PROTAC SOS1 degrader-7

Alle PROTACs Isoform-spezifische Produkte anzeigen

Alle Ras Isoform-spezifische Produkte anzeigen