2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. SOS1-IN-11

SOS1-IN-11 is a potent SOS1 inhibitor with an IC50 value of 30 nM.

For research use only. We do not sell to patients.

SOS1-IN-11 Chemical Structure

SOS1-IN-11 Chemical Structure

CAS No. : 2654741-64-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

SOS1-IN-11 is a potent SOS1 inhibitor with an IC50 value of 30 nM.

Molecular Weight

431.45

Formula

C22H24F3N5O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=NN=C(C2=CC(N3CCOCC3)=NC=C21)N[C@@H](C4=CC=CC(C(F)(F)F)=C4C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (231.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3178 mL 11.5888 mL 23.1777 mL
5 mM 0.4636 mL 2.3178 mL 4.6355 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3178 mL 11.5888 mL 23.1777 mL 57.9441 mL
5 mM 0.4636 mL 2.3178 mL 4.6355 mL 11.5888 mL
10 mM 0.2318 mL 1.1589 mL 2.3178 mL 5.7944 mL
15 mM 0.1545 mL 0.7726 mL 1.5452 mL 3.8629 mL
20 mM 0.1159 mL 0.5794 mL 1.1589 mL 2.8972 mL
25 mM 0.0927 mL 0.4636 mL 0.9271 mL 2.3178 mL
30 mM 0.0773 mL 0.3863 mL 0.7726 mL 1.9315 mL
40 mM 0.0579 mL 0.2897 mL 0.5794 mL 1.4486 mL
50 mM 0.0464 mL 0.2318 mL 0.4636 mL 1.1589 mL
60 mM 0.0386 mL 0.1931 mL 0.3863 mL 0.9657 mL
80 mM 0.0290 mL 0.1449 mL 0.2897 mL 0.7243 mL
100 mM 0.0232 mL 0.1159 mL 0.2318 mL 0.5794 mL
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SOS1-IN-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1-IN-112654741-64-5RasInhibitorinhibitorinhibit

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