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SOS1-IN-1 

Cat. No.: HY-101796
Handling Instructions

SOS1-IN-1 is a SOS1 inhibitor.

For research use only. We do not sell to patients.

SOS1-IN-1 Chemical Structure

SOS1-IN-1 Chemical Structure

CAS No. : 4551-00-2

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

SOS1-IN-1 is a SOS1 inhibitor.

IC50 & Target

SOS1[1].

In Vitro

The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with SOS1-IN-1 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0735 mL 15.3676 mL 30.7352 mL
5 mM 0.6147 mL 3.0735 mL 6.1470 mL
10 mM 0.3074 mL 1.5368 mL 3.0735 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

MIA paca-2 cells (KRAS G12 C) are subjected to a 3-day proliferation assay following treatment with SOS1-IN-1 (NSC-70220: 40 μM), treatment with NSC-658497 (30 μM) and treatment with a combination of SOS1-IN-1 (40 μM) and NSC-658497 (30 μM). DMSO is used as the negative control[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

325.36

Formula

C₂₂H₁₅NO₂

CAS No.

4551-00-2

SMILES

O=[N+]([O-])C1=CC=CC=C1/C=C/C=C2C3=CC=CC=C3C4=CC=CC=C\24

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
SOS1-IN-1
Cat. No.:
HY-101796
Quantity:

SOS1-IN-1

Cat. No.: HY-101796