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NSC-70220 

Cat. No.: HY-101796 Purity: 99.88%
Handling Instructions

NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect.

For research use only. We do not sell to patients.

NSC-70220 Chemical Structure

NSC-70220 Chemical Structure

CAS No. : 4551-00-2

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
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25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
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100 mg USD 2250 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect[1].

IC50 & Target

SOS1[1].

In Vitro

The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with NSC-70220 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of NSC-70220 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of NSC-70220 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of NSC-70220 overnight resulted in lower expression levels of P-ERK[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

325.36

Formula

C₂₂H₁₅NO₂

CAS No.

4551-00-2

SMILES

O=[N+]([O-])C1=CC=CC=C1/C=C/C=C2C3=CC=CC=C3C4=CC=CC=C\24

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (38.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0735 mL 15.3676 mL 30.7352 mL
5 mM 0.6147 mL 3.0735 mL 6.1470 mL
10 mM 0.3074 mL 1.5368 mL 3.0735 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (3.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (3.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

MIA paca-2 cells (KRAS G12 C) are subjected to a 3-day proliferation assay following treatment with SOS1-IN-1 (NSC-70220: 40 μM), treatment with NSC-658497 (30 μM) and treatment with a combination of SOS1-IN-1 (40 μM) and NSC-658497 (30 μM). DMSO is used as the negative control[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

NSC-70220NSC70220NSC 70220OthersInhibitorinhibitorinhibit

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Product Name:
NSC-70220
Cat. No.:
HY-101796
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