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SOS1-IN-1 

Cat. No.: HY-101796
Handling Instructions

SOS1-IN-1 is a SOS1 inhibitor.

For research use only. We do not sell to patients.

SOS1-IN-1 Chemical Structure

SOS1-IN-1 Chemical Structure

CAS No. : 4551-00-2

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Description

SOS1-IN-1 is a SOS1 inhibitor.

IC50 & Target

SOS1[1].

In Vitro

The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with SOS1-IN-1 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

MIA paca-2 cells (KRAS G12 C) are subjected to a 3-day proliferation assay following treatment with SOS1-IN-1 (NSC-70220: 40 μM), treatment with NSC-658497 (30 μM) and treatment with a combination of SOS1-IN-1 (40 μM) and NSC-658497 (30 μM). DMSO is used as the negative control[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

325.36

Formula

C₂₂H₁₅NO₂

CAS No.

4551-00-2

SMILES

O=[N+]([O-])C1=CC=CC=C1/C=C/C=C2C3=CC=CC=C3C4=CC=CC=C\24

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SOS1-IN-1
Cat. No.:
HY-101796
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SOS1-IN-1

Cat. No.: HY-101796