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Cat. No.: HY-151881

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SOS1-IN-15

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Based on 1 Customer Validation

SOS1-IN-15 (Compound 37) is an orally active SOS1 inhibitor with an IC₅₀ of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer.

For research use only. We do not sell to patients.

Purity: 98.04%
CAS No.: 2793404-47-2
Formula: C₂₈H₂₇F₃N₆O₂
Molecular Weight:536.55

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SOS1-IN-15 Chemical Structure

CAS No.: 2793404-47-2

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SOS1-IN-15 (Compound 37) is an orally active SOS1 inhibitor with an IC₅₀ of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer^[1].

IC₅₀ & Target^[1]

SOS1

5 nM (IC₅₀)

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MIA PaCa-2	IC₅₀	178 nM Compound: 8	Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay	[PMID: 37778239]

In Vitro

SOS1-IN-15 (Compound 37) (0.1 nM-0.1 mM; 72 h) displays prominent inhibitory activities in Mia-paca-2 cancer cells (IC₅₀ = 178 ± 42 nM)^[1].
SOS1-IN-15 has a limited inhibition of CYP and hERG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Mia-paca-2 pancreas cancer cells
Concentration:

0.1 nM-0.1 mM
Incubation Time:

72 h
Result:

Inhibited the proliferation with an IC₅₀ of 178 ± 42 nM.

In Vivo

SOS1-IN-15 (Compound 37) (50 mg/kg; p.o.; daily for 22 days) inhibits tumor volume in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude mice bearing Mia-paca-2 pancreas tumors^[1]
Dosage:

50 mg/kg
Administration:

Oral administration, daily for 22 days
Result:

Showed 49% tumor inhibition. No animal mortality and significant difference in the mice’s body weight were observed during the study period.

Animal Model:

Male CD-1 Mice^[1]
Dosage:

20 mg/kg
Administration:

Oral administration (Pharmacokinetic Analysis)
Result:

In Vivo Pharmacokinetic Properties of the Compounds in Male CD-1 Mice^a

T_1/2 (h) T_max (h) C_max (ng/mL) AUC (ng⋅h/mL) MRT (h) K_el (h^-1)

SOS1-IN-15 11.4 3.67 1550 9900 4.19 0.25

^aCompounds (20 mg/kg) were P.O. dosed in a mixture of 63% water + 30% PEG +5 % DMSO + 2% Tween 80 in male ICR mice (n = 3). Abbreviations: T_1/2, elimination half-life; T_max, plasma peak time after administration; C_max, maximum plasma concentration; AUC, area under concentration-time curve. MRT, mean residence time; K_el, elimination rate constant.

Chemical Information

CAS No. 2793404-47-2
Appearance Solid
Molecular Weight 536.55
Formula C₂₈H₂₇F₃N₆O₂
Color White to off-white
SMILES

N#CC1(CC1)C(N2CCN3C4=CC5=C(C=C4OC[C@H]3C2)N=C(C)N=C5N[C@H](C)C6=CC=CC(C(F)F)=C6F)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 100 mg/mL (186.38 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8638 mL

9.3188 mL

18.6376 mL

5 mM

0.3728 mL

1.8638 mL

3.7275 mL

10 mM

0.1864 mL

0.9319 mL

1.8638 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang S, et al. Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven Carcinoma. J Med Chem. 2022 Nov 17. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMF	1 mM	1.8638 mL	9.3188 mL	18.6376 mL	46.5940 mL
	5 mM	0.3728 mL	1.8638 mL	3.7275 mL	9.3188 mL
	10 mM	0.1864 mL	0.9319 mL	1.8638 mL	4.6594 mL
	15 mM	0.1243 mL	0.6213 mL	1.2425 mL	3.1063 mL
	20 mM	0.0932 mL	0.4659 mL	0.9319 mL	2.3297 mL
	25 mM	0.0746 mL	0.3728 mL	0.7455 mL	1.8638 mL
	30 mM	0.0621 mL	0.3106 mL	0.6213 mL	1.5531 mL
	40 mM	0.0466 mL	0.2330 mL	0.4659 mL	1.1648 mL
	50 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9319 mL
	60 mM	0.0311 mL	0.1553 mL	0.3106 mL	0.7766 mL
	80 mM	0.0233 mL	0.1165 mL	0.2330 mL	0.5824 mL
	100 mM	0.0186 mL	0.0932 mL	0.1864 mL	0.4659 mL

Keywords

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References