KRASG12C IN-15
KRASG12C IN-15 (Compound 21) is the orally active inhibitor for KRASG12C, and inhibits SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. KRASG12C IN-15 inhibits the phosphorylation of ERK with IC50 of 0.051 μM. KRASG12C IN-15 inhibits the cell viability of KRASG12C mutated MIA PaCa-2 with IC50 of 0.023 μM. KRASG12C IN-15 exhibits antitumor effect in MIA PaCa-2 xenograft mouse models.
For research use only. We do not sell to patients.
- CAS No.: 2768868-14-8
- Formula: C31H32FN3O2
- Molecular Weight:497.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2768868-14-8
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Molecular Weight 497.60
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Formula C31H32FN3O2
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SMILES
FC1=C(N2CC3(CN(C(C=C)=O)C3)CC2)N=C([C@H](C4)C(C)(C)[C@H]4C5)C5=C1C6=CC(O)=CC7=C6C=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRASG12C IN-15 Related Classifications
HY-173047 Related Classifications
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