1. GPCR/G Protein
  2. Ras
  3. RMC-0331

RMC-0331 (Synonyms: RM-023)

Cat. No.: HY-134885
Handling Instructions

RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.

For research use only. We do not sell to patients.

RMC-0331 Chemical Structure

RMC-0331 Chemical Structure

CAS No. : 2488788-52-7

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Description

RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].

In Vitro

RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

499.91

Formula

C₂₂H₂₅ClF₃N₅O₃

CAS No.
SMILES

O=C(N1CC2=NC(Cl)=NC(N[[email protected]@H](C3=CC(C(F)(F)F)=CC(N)=C3)C)=C2C1)C4(OC)CCOCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

RMC-0331RM-023RMC0331RMC 0331RM023RM 023RasselectiveoralGDPGTPexchangetumorSHP2-mutantInhibitorinhibitorinhibit

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RMC-0331
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HY-134885
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