SOS1-IN-19
SOS1-IN-19 (Compound 10i) is a potent inhibitor of SOS1 (Son of Sevenless 1) with an IC50 value of 165.2 nM. SOS1-IN-19 blocks KRAS activation by preventing GDP/GTP exchange in KRAS signaling pathway. SOS1-IN-19 is promising for research of KRAS-driven cancers (e.g., NSCLC and colorectal cancer).
For research use only. We do not sell to patients.
- Formula: C24H29F3N6O2
- Molecular Weight:490.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
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Molecular Weight 490.52
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Formula C24H29F3N6O2
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SMILES
COC1=C(OC)C=C2C(N=C(N3CC(N(C)C)C3)N=C2N[C@H](C)C4=CC(N)=CC(C(F)(F)F)=C4)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)