2. MAPK/ERK Pathway GPCR/G Protein Apoptosis
  3. SOS1 Ras Apoptosis
  4. SOS1/KRAS-IN-2

SOS1/KRAS-IN-2 (Compound 20) is a SOS1::KRASG12C protein-protein interaction inhibitor with a IC50 of 4.11 nM. SOS1/KRAS-IN-2 blocks the interaction between SOS1 and KRASG12C. SOS1/KRAS-IN-2 induces cell Apoptosis. SOS1/KRAS-IN-2 exhibits anticancer activity against colorectal cancer and tongue squamous cell carcinoma.

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SOS1/KRAS-IN-2

SOS1/KRAS-IN-2 Chemical Structure

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SOS1/KRAS-IN-2 Related Antibodies

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Description

SOS1/KRAS-IN-2 (Compound 20) is a SOS1::KRASG12C protein-protein interaction inhibitor with a IC50 of 4.11 nM. SOS1/KRAS-IN-2 blocks the interaction between SOS1 and KRASG12C. SOS1/KRAS-IN-2 induces cell Apoptosis. SOS1/KRAS-IN-2 exhibits anticancer activity against colorectal cancer and tongue squamous cell carcinoma[1].

IC50 & Target[1]

KRAS G12C-SOS1

4.11 nM (IC50)

In Vitro

SOS1/KRAS-IN-2 potently inhibits the SOS1::KRASG12C protein-protein interaction with an IC50 of 4.11 ± 0.19 nM[1].
SOS1/KRAS-IN-2 (7 days) inhibits DLD-1 colorectal cancer cell proliferation with an IC50 of 134.4 ± 5.12 nM[1].
SOS1/KRAS-IN-2 (100 μM) inhibits CAL-27 human tongue squamous carcinoma cell proliferation by 84.41 ± 10.36%[1].
SOS1/KRAS-IN-2 (100-400 nM; 24 h) induces dose-dependent apoptosis in DLD-1 colorectal cancer cells[1].
SOS1/KRAS-IN-2 (100-400 nM; 24 h) induces dose-dependent G0/G1 cell cycle arrest in DLD-1 colorectal cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SOS1/KRAS-IN-2 Related Antibodies

Apoptosis Analysis[1]

Cell Line: DLD-1 colorectal cancer cells
Concentration: 100-400 nM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner, with the percentage of apoptotic cells increasing progressively at higher concentrations.
Detected apoptosis starting at 100 nM.
Molecular Weight

441.45

Formula

C23H22F3N5O
SMILES

CC1=NC(N[C@@H](C2=CC=CC(C(F)F)=C2F)C)=C3C=C(N(C4COCC4)C=N5)C5=CC3=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SOS1/KRAS-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1/KRAS-IN-2SOS1RasApoptosisRas/Rac guanine nucleotide exchange factor 1G0/G1 cell-cycle arresthuman tongue squamous carcinoma cellcolorectal cancerCAL-27DLD-1apoptosisSOS1::KRASG12CKRASG12Ccolorectal cancer cellsInhibitorinhibitorinhibit

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