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Cat. No.: HY-181807

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SOS1/KRAS-IN-2

SOS1/KRAS-IN-2 (Compound 20) is a SOS1::KRAS^G12C protein-protein interaction inhibitor with a IC₅₀ of 4.11 nM. SOS1/KRAS-IN-2 blocks the interaction between SOS1 and KRAS^G12C. SOS1/KRAS-IN-2 induces cell Apoptosis. SOS1/KRAS-IN-2 exhibits anticancer activity against colorectal cancer and tongue squamous cell carcinoma.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₂F₃N₅O
Molecular Weight:441.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SOS1/KRAS-IN-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

KRAS G12C-SOS1

4.11 nM (IC₅₀)

All Ras Isoforms :

In Vitro

SOS1/KRAS-IN-2 potently inhibits the SOS1::KRAS^G12C protein-protein interaction with an IC₅₀ of 4.11 ± 0.19 nM^[1].
SOS1/KRAS-IN-2 (7 days) inhibits DLD-1 colorectal cancer cell proliferation with an IC₅₀ of 134.4 ± 5.12 nM^[1].
SOS1/KRAS-IN-2 (100 μM) inhibits CAL-27 human tongue squamous carcinoma cell proliferation by 84.41 ± 10.36%^[1].
SOS1/KRAS-IN-2 (100-400 nM; 24 h) induces dose-dependent apoptosis in DLD-1 colorectal cancer cells^[1].
SOS1/KRAS-IN-2 (100-400 nM; 24 h) induces dose-dependent G₀/G₁ cell cycle arrest in DLD-1 colorectal cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

DLD-1 colorectal cancer cells
Concentration:

100-400 nM
Incubation Time:

24 h
Result:

Induced apoptosis in a dose-dependent manner, with the percentage of apoptotic cells increasing progressively at higher concentrations.
Detected apoptosis starting at 100 nM.

Chemical Information

Molecular Weight 441.45
Formula C₂₃H₂₂F₃N₅O
SMILES

CC1=NC(N[C@@H](C2=CC=CC(C(F)F)=C2F)C)=C3C=C(N(C4COCC4)C=N5)C5=CC3=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang X, et al. Design, Synthesis, and Biological Evaluation of Novel 1H‑Imidazo[4,5-g]quinazoline-Based SOS1::KRAS^G12C Inhibitors in Colorectal Cancer Cells. ACS Med Chem Lett. 2026;17(3):711-720. Published 2026 Feb 16. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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SOS1/KRAS-IN-2

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SOS1/KRAS-IN-2 Related Classifications

HY-181807 Related Classifications