SOS1-IN-25
SOS1-IN-25 is an SOS1 inhibitor. SOS1-IN-25 exhibits inhibitory activity against KRASG12C/SOS1 complex formation (IC50 = 11.11 nM). SOS1-IN-25 leads to a dose-dependent decrease in pERK levels. SOS1-IN-25 can be used for the study of leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3092446-09-5
- Formula: C29H37N5O2S
- Molecular Weight:519.70
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
SOS1 11.11 nM (IC50) |
SOS1-IN-25 (Compound B5a) (72 h) exhibits good anti-proliferative activity against K562 cells (IC50 = 1.99 μM)[1].
SOS1-IN-25 (0-300 nM, 2 h) leads to a dose-dependent decrease in pERK levels in K562 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3092446-09-5
-
Molecular Weight 519.70
-
Formula C29H37N5O2S
-
SMILES
CC1=NC(N[C@@H](C2=CC(C3=CC=CC=C3CNC)=CS2)C)=C4C(C(C)(C)C(N(C5CCOCC5)C4)=O)=N1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SOS1-IN-25 Related Classifications
HY-179443 Related Classifications
Powered by Bioz