SOS1-IN-25
SOS1-IN-25 is an SOS1 inhibitor. SOS1-IN-25 exhibits inhibitory activity against KRASG12C/SOS1 complex formation (IC50 = 11.11 nM). SOS1-IN-25 leads to a dose-dependent decrease in pERK levels. SOS1-IN-25 can be used for the study of leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3092446-09-5
- Formula: C29H37N5O2S
- Molecular Weight:519.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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SOS1 11.11 nM (IC50) |
In Vitro
SOS1-IN-25 (Compound B5a) (72 h) exhibits good anti-proliferative activity against K562 cells (IC50 = 1.99 μM)[1].
SOS1-IN-25 (0-300 nM, 2 h) leads to a dose-dependent decrease in pERK levels in K562 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3092446-09-5
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Molecular Weight 519.70
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Formula C29H37N5O2S
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SMILES
CC1=NC(N[C@@H](C2=CC(C3=CC=CC=C3CNC)=CS2)C)=C4C(C(C)(C)C(N(C5CCOCC5)C4)=O)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SOS1-IN-25 Related Classifications
HY-179443 Related Classifications
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