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Cat. No.: HY-175575

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SOS1 ligand-2

SOS1 ligand-2 is a SOS1 ligand that can be used for PROTAC synthesis. SOS1 ligand-2 serves as the target protein ligand for PROTAC SOS1 degrader-4 (HY-153674). SOS1 ligand-2 is applicable to the research of KRAS-mutant cancers.

For research use only. We do not sell to patients.

CAS No.: 3027979-08-1
Formula: C₂₇H₃₁N₃O₅S
Molecular Weight:509.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SOS1 ligand-2 Chemical Structure

CAS No.: 3027979-08-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

SOS1 ligand-2 serves as the target protein ligand for PROTAC SOS1 degrader-4 (HY-153674). PROTAC SOS1 degrader-4 (compound 10) is a potent SOS1 degrader^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3027979-08-1
Molecular Weight 509.62
Formula C₂₇H₃₁N₃O₅S
SMILES

O=C(O)[C@H]1CC[C@H](C2=CC3=C(N[C@H](C)C4=CC=CC5=C4CCS5(=O)=O)N=C(C)N=C3C=C2OC)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ye Z, et al.. SOS1 degrader, preparation method and application thereof. WO202223033A1. WIPO; 2022 Oct 27.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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