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Cat. No.: HY-148261

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KRAS G12C inhibitor 56

KRAS G12C inhibitor 56 (compound IC-6) is a potent SOS1 inhibitor with an IC₅₀ of 1.6 nM. KRAS G12C inhibitor 56 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 2749963-77-5
Formula: C₃₂H₃₉N₇O₄S
Molecular Weight:617.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

KRAS G12C inhibitor 56 Chemical Structure

CAS No.: 2749963-77-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KRAS G12C inhibitor 56 (compound IC-6) is a potent SOS1 inhibitor with an IC₅₀ of 1.6 nM. KRAS G12C inhibitor 56 can be used in cancer research^[1].

IC₅₀ & Target

IC50: 1.6 nM (SOS1)^[1].

All Ras Isoforms :

Chemical Information

CAS No. 2749963-77-5
Molecular Weight 617.76
Formula C₃₂H₃₉N₇O₄S
SMILES

C=CC(N1CCC(CC1)OC2=NC(C3=CC([C@@]4(C)CCCC5=C4C(C#N)=C(S5)N)=NO3)=NC(O[C@H]([C@@H]6CCCN6C)C)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jason ABBOTT, et al. Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer. Patent WO2021245051A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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KRAS G12C inhibitor 56

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS G12C inhibitor 56 Related Classifications

HY-148261 Related Classifications