4-Chloro-3-(2,4-dioxo-1,3-diazinan-1-yl)benzoic acid
Based on 1 Customer Validation
4-Chloro-3-(2,4-dioxo-1,3-diazinan-1-yl)benzoic acid is an E3 ligase ligand that can be used in the recruitment of CRBN protein. 4-Chloro-3-(2,4-dioxo-1,3-diazinan-1-yl)benzoic acid can used to synthesis of PROTAC SOS1 degrader-4 (HY-153674) .
For research use only. We do not sell to patients.
- CAS No.: 2377645-90-2
- Formula: C11H9ClN2O4
- Molecular Weight:268.65
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
Biological Activity
Description
IC50 & Target
[1]|
Cereblon |
In Vitro
PROTAC consists of two distinct ligands linked by a linker; one is the ligand of E3 ubiquitin ligase, and the other is the ligand of the target protein. PROTAC selectively degrades target proteins by utilizing the intracellular ubiquitin-proteasome system.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 2377645-90-2
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Appearance Solid
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Molecular Weight 268.65
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Formula C11H9ClN2O4
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SMILES
O=C(O)C1=CC=C(Cl)C(=C1)N2C(=O)NC(=O)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)