PROTAC SOS1 degrader-3
PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system.
For research use only. We do not sell to patients.
- CAS No.: 3029320-99-5
- Formula: C34H32F3N7O6
- Molecular Weight:691.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cereblon |
SOS1 |
PROTAC SOS1 degrader-3 (P7; 0.1-10 μM; 6 hours) induces SOS1 degradation in SW620 cells. In addition to SW620, PROTAC SOS1 degrader-3 also induces SOS1 degradation in other colorectal cancer (CRC) cell lines HCT116, C2BB, and SW1417 in a concentration-dependent manner. The half maximal degradation concentration (DC50) for SW620, HCT116, and SW1417 at 24 h is 0.59 μM, 0.75 μM, and 0.19 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW620 cells
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Concentration:0.1 μM, 1 μM, 10 μM
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Incubation Time:6 hours
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Result:Induced SOS1 degradation.
Chemical Information
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CAS No. 3029320-99-5
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Molecular Weight 691.66
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Formula C34H32F3N7O6
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SMILES
NC1=CC(C(F)(F)F)=CC([C@H](NC2=C3C=C(OC)C(OCC(NC4=CC=CC(C5=O)=C4CN5C(C(N6)=O)CCC6=O)=O)=CC3=NC(C)=N2)C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SOS1 degrader-3 Related Classifications
HY-152145 Related Classifications
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