SOS1-IN-18
SOS1-IN-18 (Compound 8) is the inhibitor for Son of Sevenless 1 protein (SOS1) with a KD of 2.6 nM, and inhibits SOS1-KRAS G12C interaction with an IC50 of 3.4 nM. SOS1-IN-18 inhibits the phosphorylation of ERK in H358 with an IC50 of 31 nM, inhibits the proliferation of H358 with an IC50 of 5 nM.
For research use only. We do not sell to patients.
- Formula: C26H29F3N4O2
- Molecular Weight:486.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
KD: SOS1 (2.6 nM)
Chemical Information
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Molecular Weight 486.53
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Formula C26H29F3N4O2
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SMILES
O=C1C=C2C(C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3C)C)=NC4=C2CNCC4)=CN1C5CCOCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SOS1-IN-18 Related Classifications
HY-172221 Related Classifications
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