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Cat. No.: HY-161236

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KRAS ligand 4

KRAS ligand 4 (compound 2) is a bifunctional degrader based on SOS1. KRAS ligand 4 reduces downstream signaling markers pERK and pS6 and displays anti-additional activity in cells with multiple KRAS mutations.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₈ClF₃N₆O₃
Molecular Weight:540.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

KRAS ligand 4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Ras Isoforms :

In Vitro

SOS1, or SOS1 guanine nucleotide exchange factor, is a key positive regulator of the RAS signaling pathway. It catalyzes the release of GDP from RAS proteins and the binding of GTP, thereby activating RAS. SOS1 expression is aberrant in various KRAS-mutant cancers, making it an important target for developing drugs targeting the KRAS pathway. pERK/pS6 refers to phosphorylated ERK and phosphorylated S6 ribosomal proteins, downstream phosphorylation markers of the MAPK/ERK and mTOR signaling pathways, respectively. Changes in their levels are commonly used to assess the activation status of intracellular RAS/MAPK and PI3K/mTOR signaling pathways and the effects of drug targets.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 540.97
Formula C₂₄H₂₈ClF₃N₆O₃
SMILES

FC(F)(F)C1=CC([C@@H](C)NC2=NC(Cl)=NC3=C2CN(C(C4(OC)CCN(C(C)=O)CC4)=O)C3)=CC(N)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Begovich K, et al. Cereblon-Based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth. Mol Cancer Ther. 2024 Jan 15. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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