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Referencia número: HY-161236

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KRAS ligand 4

KRAS ligand 4 (compound 2) is a bifunctional degrader based on SOS1. KRAS ligand 4 reduces downstream signaling markers pERK and pS6 and displays anti-additional activity in cells with multiple KRAS mutations.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₄H₂₈ClF₃N₆O₃
Peso molecular:540.97

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

KRAS ligand 4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Ras :

In Vitro

SOS1, or SOS1 guanine nucleotide exchange factor, is a key positive regulator of the RAS signaling pathway. It catalyzes the release of GDP from RAS proteins and the binding of GTP, thereby activating RAS. SOS1 expression is aberrant in various KRAS-mutant cancers, making it an important target for developing drugs targeting the KRAS pathway. pERK/pS6 refers to phosphorylated ERK and phosphorylated S6 ribosomal proteins, downstream phosphorylation markers of the MAPK/ERK and mTOR signaling pathways, respectively. Changes in their levels are commonly used to assess the activation status of intracellular RAS/MAPK and PI3K/mTOR signaling pathways and the effects of drug targets.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 540.97
Fòrmula C₂₄H₂₈ClF₃N₆O₃
SMILES

FC(F)(F)C1=CC([C@@H](C)NC2=NC(Cl)=NC3=C2CN(C(C4(OC)CCN(C(C)=O)CC4)=O)C3)=CC(N)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Begovich K, et al. Cereblon-Based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth. Mol Cancer Ther. 2024 Jan 15. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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