2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. SOS1-IN-8

SOS1-IN-8 is a potent SOS1 inhibitor with IC50s of 11.6 and 40.7 nM for SOS1-G12D and SOS1-G12V, respectively (WO2022017339A1, compound 2).

For research use only. We do not sell to patients.

SOS1-IN-8 Chemical Structure

SOS1-IN-8 Chemical Structure

CAS No. : 2759387-92-1

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SOS1-IN-8 Related Antibodies

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Description

SOS1-IN-8 is a potent SOS1 inhibitor with IC50s of 11.6 and 40.7 nM for SOS1-G12D and SOS1-G12V, respectively (WO2022017339A1, compound 2)[1].

IC50 & Target[1]

SOS1-G12D

11.6 nM (IC50)

SOS1-G12V

40.7 nM (IC50)

Molecular Weight

477.48

Formula

C24H26F3N3O4
CAS No.
SMILES

COC1=C(C=C2C(C(C)=NN=C2N[C@@H](C3=CC=CC(C(F)(CO)F)=C3F)C)=C1)O[C@H]4CCOC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SOS1-IN-8 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1-IN-82759387-92-1RasInhibitorinhibitorinhibit

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