2759387-92-1
2759387-92-1
Chemical Structure
SOS1-IN-8
- CAS No.: 2759387-92-1
- Formula:C24H26F3N3O4
- Molecular Weight:477.48
IUPAC Name: 2,2-difluoro-2-(2-fluoro-3-((R)-1-((6-methoxy-4-methyl-7-(((S)-tetrahydrofuran-3-yl)oxy)phthalazin-1-yl)amino)ethyl)phenyl)ethan-1-ol
InChIKey: AXFAPMWBBDBMMZ-HIFRSBDPSA-N
SMILES: COC1=C(C=C2C(C(C)=NN=C2N[C@@H](C3=CC=CC(C(F)(CO)F)=C3F)C)=C1)O[C@H]4CCOC4
Biological Activity: SOS1-IN-8 is a potent SOS1 inhibitor with IC50s of 11.6 and 40.7 nM for SOS1-G12D and SOS1-G12V, respectively (WO2022017339A1, compound 2)[1].
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SOS1-IN-8 | SOS1-IN-8 is a potent SOS1 inhibitor with IC50s of 11.6 and 40.7 nM for SOS1-G12D and SOS1-G12V, respectively (WO2022017339A1, compound 2). | |||||||||||||||||||||
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