RADX - RPA1 related single stranded DNA binding protein, X-linked Gene

Also Known as CXorf57

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55086

About RADX

This gene has 6 transcripts (splice variants) and 188 orthologues. Broad expression in adrenal (RPKM 4.5), ovary (RPKM 4.0) and 24 other tissues.

Summary

Enables single-stranded DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in nuclear speck and replication fork. [provided by Alliance of Genome Resources, Apr 2022]

RADX Products (2)

mRNA Protein Name
NM_001184782.2 NP_001171711.1 RPA-related protein RADX isoform 2
NM_018015.6 NP_060485.4 RPA-related protein RADX isoform 1
Protein Preferred Names Protein Names

RPA-related protein RADX

  • RPA-related and RAD51-antagonist, X-chromosome

RADX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RADX Q6NSI4 MLH1 Homo sapiens P40692
Y2H Pooling
27229929
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schimke Immunoosseous Dysplasia

  • Schimke Immuno-Osseous Dysplasia

  • SIOD

  • Immunoosseous Dysplasia, Schimke Type

  • Schimke Syndrome

  • Immunoosseous Dysplasia Schimke Type

  • Spondyloepiphyseal Dysplasia - Nephrotic Syndrome

  • Spondyloepiphyseal Dysplasia Nephrotic Syndrome

  • Spondyloepiphyseal Dysplasia-Nephrotic Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13058B (R)-ADX-47273 Modulator 99.00% Unkown
HY-RS11616 RADX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RADX RGD RGD:1589413
Canis familiaris RADX VGNC VGNC:52594
Mus musculus RADX MGD MGI:2147848
Bos taurus RADX VGNC VGNC:52760
Others RADX NCBI