PTPN3 - protein tyrosine phosphatase non-receptor type 3 Gene

Also Known as PTPH1; PTP-H1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5774

About PTPN3

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:109,375,694-109,538,420 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 9.4), kidney (RPKM 7.8) and 21 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. p97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

PTPN3 Products (6)

mRNA	Protein	Name
NM_001145368.2	NP_001138840.1	tyrosine-protein phosphatase non-receptor type 3 isoform 2
NM_001145369.2	NP_001138841.1	tyrosine-protein phosphatase non-receptor type 3 isoform 3
NM_001145370.2	NP_001138842.1	tyrosine-protein phosphatase non-receptor type 3 isoform 4
NM_001145371.2	NP_001138843.1	tyrosine-protein phosphatase non-receptor type 3 isoform 5
NM_001145372.2	NP_001138844.1	tyrosine-protein phosphatase non-receptor type 3 isoform 6
NM_002829.4	NP_002820.3	tyrosine-protein phosphatase non-receptor type 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	10364224	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	10364224	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9341175	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	19167335	GOA
enables sodium channel regulator activity	IDA IDA: Inferred from direct assay	16930557	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	12207026	GOA
involved in negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	10364224	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	10364224	GOA
involved in regulation of membrane depolarization during action potential	IDA IDA: Inferred from direct assay	16930557	GOA
involved in regulation of sodium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	16930557	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10940933	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	10940933	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN3 Protein Structure

FERM_N

FERM_M

FERM_C

PDZ

Y_phosphatase

0
200
400
600
800
913 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 3	cytoskeletal-associated protein tyrosine phosphatase

PTPN3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPN3	P26045	DIP2A	Homo sapiens	Q14689-6	Validated Y2H	25416956
Intra	PTPN3	P26045	DIP2A	Homo sapiens	Q14689-6	Y2H Array	25416956
Intra	PTPN3	P26045	VANGL2	Homo sapiens	Q9ULK5	Anti Tag CoIP	28330616
Intra	PTPN3	P26045	VANGL2	Homo sapiens	Q9ULK5	Pull Down	28330616
Intra	PTPN3	P26045	SDHA	Homo sapiens	P31040	Pull Down	28330616
Intra	PTPN3	P26045	SDHA	Homo sapiens	P31040	Anti Tag CoIP	28330616
Cross	PTPN3	P26045	E6	Human papillomavirus	P06463	Pull Down	17947517
Cross	PTPN3	P26045	E6	Human papillomavirus	P06463	CoIP	17947517
Intra	PTPN3	P26045	SRCAP	Homo sapiens	Q6ZRS2-3	Validated Y2H	32296183
Intra	PTPN3	P26045	VWA2	Homo sapiens	Q5GFL6-3	Validated Y2H	32296183
Intra	PTPN3	P26045	WDR6	Homo sapiens	Q9NNW5	Validated Y2H	32296183
Intra	PTPN3	P26045	EPS15	Homo sapiens	P42566-1	X-Ray Diffraction	25728925
Intra	PTPN3	P26045	EPS15	Homo sapiens	P42566-1	FPS	25728925
Intra	PTPN3	P26045	EPS15	Homo sapiens	P42566-1	Anti Tag CoIP	25728925
Intra	PTPN3	P26045	EPS15	Homo sapiens	P42566-1	Phosphatase Assay	25728925
Intra	PTPN3	P26045	AKR1C1	Homo sapiens	Q04828	Y2H Prey Pooling	25416956
Intra	PTPN3	P26045	AKR1C1	Homo sapiens	Q04828	Validated Y2H	32296183
Intra	PTPN3	P26045	AKR1C1	Homo sapiens	Q04828	Y2H Array	32296183
Intra	PTPN3	P26045	TFAP4	Homo sapiens	Q01664	Validated Y2H	32296183
Intra	PTPN3	P26045	VDR	Homo sapiens	P11473	Anti Tag CoIP	21119599
Intra	PTPN3	P26045	MCC	Homo sapiens	P23508	Anti Tag CoIP	28330616
Intra	PTPN3	P26045	MCC	Homo sapiens	P23508	Pull Down	28330616
Intra	PTPN3	P26045	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	PTPN3	P26045	YWHAZ	Homo sapiens	P63104	BioID	28330616
Intra	PTPN3	P26045	YWHAZ	Homo sapiens	P63104	Pull Down	28330616
Intra	PTPN3	P26045	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	27880917
Intra	PTPN3	P26045	VCP	Homo sapiens	P55072	Pull Down	10364224
Intra	PTPN3	P26045	YWHAB	Homo sapiens	P31946	Pull Down	28330616
Intra	PTPN3	P26045	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	27880917
Intra	PTPN3	P26045	YWHAB	Homo sapiens	P31946	BioID	28330616
Intra	PTPN3	P26045	YWHAB	Homo sapiens	P31946	Pull Down	9341175
Intra	PTPN3	P26045	YWHAG	Homo sapiens	P61981	BioID	28330616
Intra	PTPN3	P26045	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	27880917
Intra	PTPN3	P26045	YWHAG	Homo sapiens	P61981	Pull Down	28330616
Intra	PTPN3	P26045	YWHAG	Homo sapiens	P61981	Y2H Pooling	20936779
Intra	PTPN3	P26045	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	25416956
Intra	PTPN3	P26045	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	25416956
Intra	PTPN3	P26045	VANGL1	Homo sapiens	Q8TAA9	Anti Tag CoIP	28330616
Intra	PTPN3	P26045	VANGL1	Homo sapiens	Q8TAA9	BioID	28330616
Intra	PTPN3	P26045	VANGL1	Homo sapiens	Q8TAA9	Pull Down	28330616
Intra	PTPN3	P26045	VANGL1	Homo sapiens	Q8TAA9	Anti Tag CoIP	27880917
Intra	PTPN3	P26045	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	PTPN3	P26045	SCN5A	Homo sapiens	Q14524	Pull Down	16930557
Intra	PTPN3	P26045	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	PTPN3	P26045	MLH1	Homo sapiens	P40692	Validated Y2H	32296183
Intra	PTPN3	P26045	MTMR9	Homo sapiens	Q96QG7	Validated Y2H	32296183
Intra	PTPN3	P26045	TENT5D	Homo sapiens	Q8NEK8	Validated Y2H	32296183
Intra	PTPN3	P26045	NXT2	Homo sapiens	Q9NPJ8	Validated Y2H	25416956
Intra	PTPN3	P26045	NXT2	Homo sapiens	Q9NPJ8	Y2H Array	25416956
Intra	PTPN3	P26045	LMO1	Homo sapiens	P25800	Y2H Array	25416956
Intra	PTPN3	P26045	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PTPN3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89601	PTP-H1 Antibody (YA8945)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Hyperinsulinemic Hypoglycemia, Familial, 5	Hyperinsulinism Due To Insr Deficiency HHF5 Familial Hyperinsulinemic Hypoglycemia 5 Hyperinsulinemic Hypoglycemia Due To Insr Deficiency Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency Congenital Hyperinsulinism Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi Hyperinsulinemic Hypoglycemia Familial 5
Monocarboxylate Transporter 1 Deficiency	Ketoacidosis Due To Monocarboxylate Transporter-1 Deficiency MCT1D Ketosis
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11426	PTPN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19232	Ptpn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25721	Ptpn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTPN3	VGNC	VGNC:33538
Felis catus	PTPN3	VGNC	VGNC:69163
Rattus norvegicus	PTPN3	RGD	RGD:1311363
Canis familiaris	PTPN3	VGNC	VGNC:45176
Macaca mulatta	PTPN3	VGNC	VGNC:76604
Mus musculus	PTPN3	MGD	MGI:105307
Others	PTPN3	NCBI