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WDR6 - WD repeat domain 6 Gene

Also Known as Trm734

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11180

About WDR6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,007,391-49,015,951 (from NCBI)

This gene has 22 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in ovary (RPKM 54.4), endometrium (RPKM 45.4) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

WDR6 Products (3)

mRNA	Protein	Name
NM_001320546.3	NP_001307475.1	WD repeat-containing protein 6 isoform 2
NM_001320547.2	NP_001307476.1	WD repeat-containing protein 6 isoform 3
NM_018031.6	NP_060501.4	WD repeat-containing protein 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme regulator activity	IDA IDA: Inferred from direct assay	32558197	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17216128	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	32558197	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of negative effect G1 to G0 transition	IPI IPI: Inferred from physical interaction	17216128	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22354037	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17216128	GOA
involved in wobble position ribose methylation	IDA IDA: Inferred from direct assay	32558197	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17216128	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR6 Protein Structure

WD40

0
200
400
600
800
1000
1121 a.a.

Protein Preferred Names	Protein Names
WD repeat-containing protein 6	Trm734 homolog

WDR6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WDR6	Q9NNW5	PTPN3	Homo sapiens	P26045	Y2H Prey Pooling	32296183
Intra	WDR6	Q9NNW5	PTPN3	Homo sapiens	P26045	Y2H Array	25416956
Intra	WDR6	Q9NNW5	PTPN3	Homo sapiens	P26045	Y2H Array	32296183
Intra	WDR6	Q9NNW5	PTPN3	Homo sapiens	P26045	Validated Y2H	25416956
Intra	WDR6	Q9NNW5	PTPN3	Homo sapiens	P26045	Y2H Prey Pooling	25416956
Intra	WDR6	Q9NNW5	GRIP1	Homo sapiens	Q9Y3R0-3	Y2H Prey Pooling	32296183
Intra	WDR6	Q9NNW5	GRIP1	Homo sapiens	Q9Y3R0-3	Validated Y2H	32296183
Intra	WDR6	Q9NNW5	GRIP1	Homo sapiens	Q9Y3R0-3	Y2H Array	32296183
Intra	WDR6	Q9NNW5	STK11	Homo sapiens	Q15831	Y2H	17216128

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Tumoral Calcinosis, Normophosphatemic, Familial	Normophosphatemic Familial Tumoral Calcinosis NFTC Tumoral Calcinosis, Familial, Normophosphatemic Calcinosis, Tumoral, With Normophosphatemia Familial Normophosphatemic Tumoral Calcinosis Tumoral Calcinosis With Normophosphatemia
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15790	WDR6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WDR6	VGNC	VGNC:36908
Macaca mulatta	WDR6	VGNC	VGNC:78790
Rattus norvegicus	WDR6	RGD	RGD:1307649
Mus musculus	WDR6	MGD	MGI:1930140
Canis familiaris	WDR6	VGNC	VGNC:48378
Felis catus	WDR6	VGNC	VGNC:67043
Others	WDR6	NCBI