SYF2 - SYF2 pre-mRNA splicing factor Gene

Also Known as P29; CBPIN; NTC31; fSAP29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25949

About SYF2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:25,222,276-25,232,502 (from NCBI)

This gene has 4 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in bone marrow (RPKM 39.9), ovary (RPKM 37.8) and 25 other tissues.

Summary

This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SYF2 Products (2)

mRNA Protein Name
NM_015484.5 NP_056299.1 pre-mRNA-splicing factor SYF2 isoform 1
NM_207170.4 NP_997053.1 pre-mRNA-splicing factor SYF2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28076346 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYF2 Protein Structure

SYF2

SYF2: SYF2 splicing factor (90 - 238)

  • 0
  • 100
  • 200
  • 243 a.a.
Protein Preferred Names Protein Names

pre-mRNA-splicing factor SYF2

  • CCNDBP1 interactor

SYF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SYF2 O95926 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra
SYF2 O95926 MLH1 Homo sapiens P40692
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14074 SYF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SYF2 VGNC VGNC:78174
Rattus norvegicus SYF2 RGD RGD:621592
Bos taurus SYF2 VGNC VGNC:35512
Mus musculus SYF2 MGD MGI:1915842